DNASE1L2 and CD5

		DNASE1L2	CD5
Description		deoxyribonuclease 1 like 2	CD5 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Calcium Ion Binding Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Hair Follicle Development Corneocyte Development DNA Metabolic Process DNA Catabolic Process	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088 24076602) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		1 interacting genes: CD5	27 interacting genes: CAMK2D CAPN1 CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CFL1 CSNK2A1 CTTN DNASE1L2 DYNLT3 FYN HNRNPU LCK MX1 PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70 ZNHIT2
Entrez ID		1775	921
HPRD ID		04018	01078
Ensembl ID		ENSG00000167968	ENSG00000110448
Uniprot IDs		Q92874	P06127
PDB IDs			2JA4 2JOP 2JP0 2OTT
Enriched GO Terms of Interacting Partners?		T Cell Costimulation	Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion
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