PLK2 and TUBA1A

Number of citations of the paper that reports this interaction (PubMedID 20802490)
50

Data Source:
BioGRID (pull down)

		PLK2	TUBA1A
Description		polo like kinase 2	tubulin alpha 1a
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Dendrite Cell Projection	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Negative Regulation Of Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response NPAS4 regulates expression of target genes	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Fostamatinib	Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Multisite chronic pain ( 33830993) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)	Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)
Interacting Genes		16 interacting genes: AP1B1 AP1G1 AP2A1 APP CASK CDC20B CENPU CIB1 DNM1 MPP3 NEDD4 NRIP1 NSF TSC1 TSC2 TUBA1A	69 interacting genes: ACVR1B AMHR2 ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBA1C TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		10769	7846
HPRD ID		06118	03959
Ensembl ID		ENSG00000145632	ENSG00000167552
Uniprot IDs		A0A087WUH9 Q9NYY3	Q71U36
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0	5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Intracellular Protein Transport Endocytosis Membrane Coat Establishment Of Localization In Cell TSC1-TSC2 Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Vesicle-mediated Transport Basolateral Protein Secretion Import Into Cell Lysosomal Membrane Cellular Localization Protein Transport Perinuclear Region Of Cytoplasm Positive Regulation Of Protein Catabolic Process Clathrin Adaptor Complex AP-1 Adaptor Complex Adult Locomotory Behavior Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Synapse Organization Establishment Of Protein Localization Associative Learning Golgi Apparatus Filopodium Tip Clathrin Adaptor Activity Post-Golgi Vesicle-mediated Transport Melanosome Assembly Synapse Positive Regulation Of Catabolic Process Trans-Golgi Network Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-matrix Adhesion Platelet Dense Granule Organization Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Regulation Of Transport Regulation Of Protein Catabolic Process Adult Behavior Ionotropic Glutamate Receptor Binding Negative Regulation Of Cell Population Proliferation Learning Cytosol Vesicle Budding From Membrane Clathrin-coated Vesicle Membrane Receptor-mediated Endocytosis Melanosome Organization Negative Regulation Of Macroautophagy Pigment Granule Organization	Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?