DLST and PAK4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	PAK4
Description		dihydrolipoamide S-succinyltransferase	p21 (RAC1) activated kinase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-macromolecule Adaptor Activity Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Stabilization Dendritic Spine Development Cell-cell Adhesion Positive Regulation Of Focal Adhesion Disassembly Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		23 interacting genes: ACYP1 ARIH2 CCDC86 DLG5 ESRRB FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1	23 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAZ
Entrez ID		1743	10298
HPRD ID		00520	05675
Ensembl ID		ENSG00000119689	ENSG00000130669
Uniprot IDs		B7Z6J1 P36957	O96013
PDB IDs		6H05	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY 7CMB 7CP3 7CP4 7S46 7S47 7S48 8AHG 8AHH 8AHI 8YHK
Enriched GO Terms of Interacting Partners?			Focal Adhesion Integrin Alphav-beta5 Complex Intracellular Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Actin Filament-based Process Endodermal Cell Differentiation Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Shelterin Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Of Golgi Localization Positive Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Nucleus Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Protein Localization Receptor Complex Regulation Of Intracellular Signal Transduction Phosphorylation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Telomere Capping Golgi Localization Innate Immune Response Organelle Organization Negative Regulation Of Immune Response Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Macromolecule Metabolic Process Phagocytic Vesicle Protein Domain Specific Binding Chromosome Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endocytosis Identical Protein Binding Phosphate-containing Compound Metabolic Process Negative Regulation Of Innate Immune Response Integrin-mediated Signaling Pathway Defense Response To Symbiont Negative Regulation Of Telomere Maintenance Via Telomerase Actin Filament Organization Small GTPase-mediated Signal Transduction Fibroblast Growth Factor Binding Negative Regulation Of Lipid Storage
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