DLST and ESRRB

		DLST	ESRRB
Description		dihydrolipoamide S-succinyltransferase	estrogen related receptor beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Integrator Complex
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Embryonic Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Stem Cell Division Stem Cell Population Maintenance Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Morula Formation Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation
Pathways		Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA	Nuclear Receptor transcription pathway
Drugs			Diethylstilbestrol Genistein Flavone
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)
Interacting Genes		23 interacting genes: ACYP1 ARIH2 CCDC86 DLG5 ESRRB FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1	8 interacting genes: DLST HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1
Entrez ID		1743	2103
HPRD ID		00520	03700
Ensembl ID		ENSG00000119689	ENSG00000119715
Uniprot IDs		B7Z6J1 P36957	A0A2R8Y491 E7EWD9 O95718
PDB IDs		6H05	1LO1 6LIT 6LN4
Enriched GO Terms of Interacting Partners?			Histone Deacetylase Binding Nuclear Receptor Binding Disordered Domain Specific Binding Protein Dimerization Activity Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Nucleoplasm Protein-containing Complex Positive Regulation Of Biosynthetic Process Transcription Coregulator Activity Chromatin Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Folding Chaperone Complex Response To Hormone ATP-dependent Protein Folding Chaperone Cellular Response To Estradiol Stimulus Positive Regulation Of Developmental Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Post-translational Protein Modification Tau Protein Binding Rhythmic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Heat Transcription Coactivator Activity Ubiquitin Protein Ligase Binding Euchromatin Protein Folding Chaperone Nucleus Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Cellular Response To Hormone Stimulus Dihydrolipoyllysine-residue Succinyltransferase Activity
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