DKC1 and LYPLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DKC1	LYPLA2
Description		dyskerin pseudouridine synthase 1	lysophospholipase 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Golgi Stack Cytosol Extracellular Exosome
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding	Phosphatidylcholine Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity Cadherin Binding
	Biological Process	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA Sno(s)RNA 3'-end Processing Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RNA Modification RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Box H/ACA Sno(s)RNA Metabolic Process Ribosome Biogenesis ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body Telomerase Holoenzyme Complex Assembly MRNA Pseudouridine Synthesis	Lipid Metabolic Process Fatty Acid Metabolic Process Axon Guidance Acylglycerol Catabolic Process Macromolecule Depalmitoylation Prostaglandin Catabolic Process
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	L1CAM interactions
Drugs
Diseases		Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS
Interacting Genes		10 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SSR1 TERC	5 interacting genes: APP DKC1 INCA1 MED31 SCMH1
Entrez ID		1736	11313
HPRD ID		02129	07127
Ensembl ID		ENSG00000130826	ENSG00000011009
Uniprot IDs		A0A8Q3SIY6 O60832	A0A140VJC9 O95372
PDB IDs		7BGB 7TRC 7V9A 8OUE 8OUF	5SYN 6BJE
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Box H/ACA SnoRNA Binding Protein Localization To Nucleoplasm SnRNA Pseudouridine Synthesis Protein Localization To Cajal Body Box H/ACA Sno(s)RNA Metabolic Process Box H/ACA SnoRNP Complex Box H/ACA Sno(s)RNA 3'-end Processing Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA ScaRNP Complex Telomerase RNA Stabilization Negative Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Box H/ACA Telomerase RNP Complex ScaRNA Localization To Cajal Body Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway SnRNA Modification Telomerase Holoenzyme Complex Assembly Regulation Of Primary Metabolic Process
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