NLRP6 and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 36223738)
0

Data Source:
BioGRID (pull down)

		NLRP6	ATG16L1
Description		NLR family pyrin domain containing 6	autophagy related 16 like 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Membraneless Organelle Canonical Inflammasome Complex NLRP6 Inflammasome Complex	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Double-stranded RNA Binding Vasopressin Receptor Activity ATP Binding Signaling Adaptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Binding Lipoteichoic Acid Binding Molecular Condensate Scaffold Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding
	Biological Process	Immune System Process Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Secretion Response To Bacterium Regulation Of Autophagy Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Interleukin-18-mediated Signaling Pathway Wound Healing Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Innate Immune Response Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Immune Response Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Defense Response To Virus Regulation Of Mucus Secretion Necroptotic Process Pyroptotic Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Neutrophil-mediated Killing Of Gram-positive Bacterium Antiviral Innate Immune Response NLRP6 Inflammasome Complex Assembly Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension
Pathways			Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: ATG12 ATG16L1 ATG5 BECN1 PIK3R1 SQSTM1	23 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 IFT20 NLRP6 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B RIPK2 SCAP SETD7 TRAF3IP3 WIPI2 ZFP36
Entrez ID		171389	55054
HPRD ID		14806	16498
Ensembl ID		ENSG00000174885	ENSG00000085978
Uniprot IDs		P59044	E7EVC7 Q17RG0 Q676U5
PDB IDs		6NCV 6NDJ	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG
Enriched GO Terms of Interacting Partners?		Autophagosome Macroautophagy Atg12-Atg5-Atg16 Complex Autophagy Of Mitochondrion Autophagy Autophagosome Assembly Autophagosome Organization Regulation Of Autophagy Phagophore Assembly Site Membrane Microautophagy Regulation Of Innate Immune Response Positive Regulation Of Viral Translation Vacuole Organization Positive Regulation Of Autophagy Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Organelle Assembly Mitophagy Regulation Of Defense Response Response To Mitochondrial Depolarisation Response To Iron(II) Ion Positive Regulation Of Stress Granule Assembly Viral RNA Genome Replication Regulation Of Immune Response Cellular Response To Nitrogen Starvation Regulation Of Stress Granule Assembly Transferase Complex Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Organelle Organization Aggrephagy Regulation Of Autophagosome Maturation Negative Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Defense Response To Virus Positive Regulation Of Catabolic Process Piecemeal Microautophagy Of The Nucleus Viral Genome Replication Nucleophagy Regulation Of Macroautophagy Cellular Localization Establishment Of Localization In Cell Regulation Of Immune System Process Phagophore Assembly Site Response To Iron Ion Regulation Of Toll-like Receptor 4 Signaling Pathway GTPase Binding Defense Response To Virus Nucleobase-containing Compound Biosynthetic Process Catabolic Process	Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response
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