ATG16L1 and PLD3

		ATG16L1	PLD3
Description		autophagy related 16 like 1	phospholipase D family member 3
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endosome Membrane Endomembrane System Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Protein Binding Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension	Immune System Process DNA Metabolic Process Lipid Metabolic Process Inflammatory Response Myotube Differentiation Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Macroautophagy	Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases		Crohn's disease
GWAS		Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		23 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN GIGYF2 IFT20 NLRP6 NOD1 NOD2 OPTN PLD3 RAB33A RAB33B RIPK2 SCAP SETD7 TRAF3IP3 WIPI2 ZFP36	16 interacting genes: ANXA7 ATG16L1 BCL2L1 CIC CNIH3 GPR35 HGS NFKB1 OGT OPRM1 SMCO4 SOX4 SPP1 STK11 TK1 VRK2
Entrez ID		55054	23646
HPRD ID		16498	07148
Ensembl ID		ENSG00000085978	ENSG00000105223
Uniprot IDs		E7EVC7 Q17RG0 Q676U5	Q8IV08
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG	8Q1K 8Q1X 8S86 8V5T
Enriched GO Terms of Interacting Partners?		Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response	Regulation Of Transport Autophagy Negative Regulation Of Developmental Process Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Process Regulation Of Neurotransmitter Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Alkaloid Mitochondrial Membrane Regulation Of Signal Transduction Apoptotic Process In Bone Marrow Cell Positive Regulation Of Transport Regulation Of Signaling Receptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macroautophagy Vacuole-isolation Membrane Contact Site Response To Ketone Regulation Of Protein Localization Negative Regulation Of Growth Synapse Regulation Of Cellular Response To Stress Protein Localization To Lysosome Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Reproductive Process Regulation Of Canonical Wnt Signaling Pathway NF-kappaB P50/p65 Complex Regulation Of Secretion By Cell Cellular Response To Glucose Stimulus Positive Regulation Of Estradiol Secretion Thymidine Kinase Activity C-terminal Protein Lipidation Regulation Of Growth Mitochondrion Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Positive Regulation Of Lipid Transport Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex
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