BHLHA15 and TCF3

Number of citations of the paper that reports this interaction (PubMedID 9073453)
0

Data Source:
HPRD (in vivo, in vitro)

		BHLHA15	TCF3
Description		basic helix-loop-helix family member a15	transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Glandular Epithelial Cell Maturation Mitochondrial Calcium Ion Transmembrane Transport Golgi Organization G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Organ Development Negative Regulation Of Myotube Differentiation Calcium-mediated Signaling Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Glucose Starvation Glucose Homeostasis Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization Positive Regulation Of Transcription By RNA Polymerase II Intracellular Distribution Of Mitochondria Establishment Of Localization In Cell Localization Of Cell Axon Development Type B Pancreatic Cell Maturation	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Developmental Lineage of Pancreatic Acinar Cells	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS			Hodgkin's lymphoma ( 24920014 29196614) Monocyte count ( 32888494) Objective response to lithium treatment ( 26503763) Triglyceride levels ( 34074324)
Interacting Genes		4 interacting genes: CFTR MYOD1 MYOG TCF3	67 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TNFSF14 TRRAP TWIST1 UBE2I USF1
Entrez ID		168620	6929
HPRD ID		16356	00918
Ensembl ID		ENSG00000180535	ENSG00000071564
Uniprot IDs		Q7RTS1	P15923
PDB IDs			2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?		E-box Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Protein Dimerization Activity Muscle Cell Fate Commitment Cell Fate Commitment Transcription Regulator Complex Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Myotube Differentiation DNA-binding Transcription Activator Activity Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Fiber Development BHLH Transcription Factor Binding Myotube Cell Development Cellular Response To Estradiol Stimulus Positive Regulation Of Developmental Process Regulation Of Striated Muscle Tissue Development Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Euchromatin Cellular Response To Lipid Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Development Striated Muscle Cell Development Striated Muscle Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Chromatin DNA Binding Regulation Of Striated Muscle Cell Differentiation Muscle Cell Development Cellular Response To Tumor Necrosis Factor Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DNA-binding Transcription Factor Activity Muscle Cell Differentiation Response To Estradiol Response To Tumor Necrosis Factor Muscle Organ Development Striated Muscle Tissue Development Response To Lipid Regulation Of Developmental Process Muscle Structure Development Positive Regulation Of Anion Channel Activity	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis
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