BHLHA15 and MYOD1

Number of citations of the paper that reports this interaction (PubMedID 9482738)
36

Data Source:
HPRD (in vitro)

		BHLHA15	MYOD1
Description		basic helix-loop-helix family member a15	myogenic differentiation 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Myofibril
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Glandular Epithelial Cell Maturation Mitochondrial Calcium Ion Transmembrane Transport Golgi Organization G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Organ Development Negative Regulation Of Myotube Differentiation Calcium-mediated Signaling Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Glucose Starvation Glucose Homeostasis Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization Positive Regulation Of Transcription By RNA Polymerase II Intracellular Distribution Of Mitochondria Establishment Of Localization In Cell Localization Of Cell Axon Development Type B Pancreatic Cell Maturation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Tissue Development Regulation Of Gene Expression Myotube Differentiation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		Developmental Lineage of Pancreatic Acinar Cells	Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases
GWAS			Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		4 interacting genes: CFTR MYOD1 MYOG TCF3	67 interacting genes: AKAP19 AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		168620	4654
HPRD ID		16356	01166
Ensembl ID		ENSG00000180535	ENSG00000129152
Uniprot IDs		Q7RTS1	P15172
PDB IDs
Enriched GO Terms of Interacting Partners?		E-box Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Protein Dimerization Activity Muscle Cell Fate Commitment Cell Fate Commitment Transcription Regulator Complex Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Myotube Differentiation DNA-binding Transcription Activator Activity Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Fiber Development BHLH Transcription Factor Binding Myotube Cell Development Cellular Response To Estradiol Stimulus Positive Regulation Of Developmental Process Regulation Of Striated Muscle Tissue Development Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Euchromatin Cellular Response To Lipid Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Development Striated Muscle Cell Development Striated Muscle Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Chromatin DNA Binding Regulation Of Striated Muscle Cell Differentiation Muscle Cell Development Cellular Response To Tumor Necrosis Factor Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding DNA-binding Transcription Factor Activity Muscle Cell Differentiation Response To Estradiol Response To Tumor Necrosis Factor Muscle Organ Development Striated Muscle Tissue Development Response To Lipid Regulation Of Developmental Process Muscle Structure Development Positive Regulation Of Anion Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of Macromolecule Metabolic Process BHLH Transcription Factor Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Nucleoplasm Histone Deacetylase Binding Regulation Of Developmental Process E-box Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Differentiation Cell Differentiation Regulation Of Metabolic Process Circadian Rhythm Positive Regulation Of Cell Differentiation Cellular Developmental Process Transcription Cis-regulatory Region Binding Negative Regulation Of Developmental Process
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