DEFA1 and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		DEFA1	PFDN1
Description		defensin alpha 1	prefoldin subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Protein Binding Pore-forming Activity	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Defensins Alpha-defensins Neutrophil degranulation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		7 interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		1667	5201
HPRD ID		00499	05357
Ensembl ID		ENSG00000206047	ENSG00000113068
Uniprot IDs		P59665	O60925
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Systemic Arterial Blood Pressure Complement Component C1q Complex IgM Binding Complement Component C1 Complex Cell Surface Blood Microparticle Disruption Of Plasma Membrane Integrity In Another Organism Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Superior Temporal Gyrus Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Proteolysis Regulation Of Protein Metabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Protease Binding Regulation Of Glycogen (starch) Synthase Activity Viral Process Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Blood Pressure Regulation Of Tube Size Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Viral Translation Viral Life Cycle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Tryptophan Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cilium Positive Regulation Of Gap Junction Assembly Pore-forming Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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