DEFA1

Description		defensin alpha 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Pore-forming Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Defensins Alpha-defensins Neutrophil degranulation
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chromium levels ( 26025379) Dental caries (decayed and filled deciduous teeth) ( 31533690) Endometriosis ( 28333195) Periodontitis (PAL4Q3) ( 24024966)
Novel Interacting Genes		7 novel interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Interacting Genes		7 interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Entrez ID		1667
HPRD ID		00499
Ensembl ID		ENSG00000206047
Uniprot IDs		P59665
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Systemic Arterial Blood Pressure Complement Component C1q Complex IgM Binding Complement Component C1 Complex Cell Surface Blood Microparticle Disruption Of Plasma Membrane Integrity In Another Organism Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Superior Temporal Gyrus Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Proteolysis Regulation Of Protein Metabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Protease Binding Regulation Of Glycogen (starch) Synthase Activity Viral Process Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Blood Pressure Regulation Of Tube Size Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Viral Translation Viral Life Cycle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Tryptophan Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cilium Positive Regulation Of Gap Junction Assembly Pore-forming Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome
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