TLE5 and DCUN1D1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		TLE5	DCUN1D1
Description		TLE family member 5, transcriptional modulator	defective in cullin neddylation 1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Wnt Signaling Pathway Regulation Of Growth Negative Regulation Of DNA-templated Transcription Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	Regulation Of Protein Ubiquitination Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Repression of WNT target genes	Neddylation
Drugs
Diseases
GWAS			Fasting insulin ( 34074324) Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		367 interacting genes: ABI2 ACTMAP AEN AGR2 AIRIM AKAP8L AMH ANAPC11 ANKRD11 AR ARHGAP32 ARX ASB3 ATN1 ATOSB ATP6V0D1 BAG4 BAHD1 BCL6 BHLHE40 BIRC7 BPIFA1 BYSL C10orf55 C14orf119 C1orf216 C1orf94 C7orf57 CABP2 CABP4 CABP5 CALCOCO2 CAPN1 CARD9 CATSPERT CCDC120 CCDC57 CCL7 CCNJL CCNK CFAP206 CFAP68 CIB3 CLIC3 CLIP3 CNFN COA7 CPSF7 CRACR2A CSNK1E CSNK2A1 CSTF2 CSTF2T CT55 CTBP2 CYSRT1 DAZAP2 DCUN1D1 DDX6 DGCR6 DIP2A DMRT2 DMRT3 DMRTB1 DNMT3L DOK6 DVL2 DVL3 DYDC1 EAF1 EAF2 EFEMP2 EFHC1 EIF1AD EIF4E2 ERF EXOSC5 EYA2 FAM124A FAM124B FAM168B FAM217B FAM90A1 FANCG FBF1 FBLN1 FCHSD2 FHL3 FOSB FOXD2 FOXN1 FOXP2 FRS3 FSD2 FXR1 FXR2 GABARAP GATA1 GCC1 GEM GFAP GFI1B GIGYF1 GLIS2 GLRX3 GOLGA2 GOLGA6L9 GORASP2 GPANK1 GPATCH2L GRAP2 GRB2 GRN GTF2E1 GYS1 HCN2 HDAC4 HDHD3 HELT HEXIM2 HGS HHEX HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPK HNRNPLL HOMEZ HOXA1 HOXB5 HOXC8 HOXC9 IKZF3 INO80B INO80E INPP5J IRX2 IRX6 KANK2 KDM1A KIFC3 KLF1 KLF4 KLHDC7B KRT13 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP10-11 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 L3MBTL2 LDLR LDOC1 LENG8 LINC00526 LMO1 LMO2 LMO4 LSM2 LZTS2 MAGOHB MAPK1 MAPK14 MAPRE3 MBNL1 MCRS1 MDFI MECOM MED12L MED25 MED31 MED4 MEIS3 MFAP1 MIA2 MIIP MKRN3 MLH1 MLLT6 MLX MORF4L1 MORF4L2 MSS51 MSX1 MSX2 MTUS2 MVP MYF5 MYH7B MYO15B MYOG NAB2 NAF1 NBPF19 NCDN NDOR1 NDUFB7 NEK6 NLGN3 NOTCH2NLA NTAQ1 NUDT22 NUTF2 NUTM1 OLIG3 OSGIN1 OXER1 P4HA3 PARVG PATZ1 PCBP1 PCSK5 PFDN5 PHF1 PHKB PICK1 PITX1 PITX2 PLAGL1 POLR1C POU2F1 PPP1R16A PPP1R16B PRDM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRKAB2 PROP1 PRPF31 PRR3 PRR35 PSMB1 PSMB4 PSMF1 PTRH2 QARS1 RAD51D RBM10 RBPMS REL RELA RFX6 RHOXF2 RIBC1 RIMBP3 RNF31 RORB RPL18A RUNX1 RUSC1 SAT1 SCNM1 SDCBP SERTAD3 SET SF3B4 SH2B2 SH3GL3 SHFL SHISA6 SIX1 SIX2 SIX3 SIX6 SKIL SKP2 SMAD3 SMAD4 SMARCB1 SMARCD1 SNCAIP SNRPA SNRPC SOHLH1 SPATA25 SPG21 SPMIP9 SRPK2 SSC4D STK16 STX11 SUFU SUPT5H TBX3 TBX6 TCEANC TCF4 TCF7L2 TEAD4 TENT5B TFAP2D THAP7 TIGD3 TMCC2 TNS2 TOX3 TRAF1 TRAF2 TRIB3 TRIM26 TRIM27 TRIM41 TRIP6 TRMT2A TSC1 TSC22D4 TSEN15 TSGA10 TSGA10IP TSSK3 TTC23 U2AF2 UBAP2 UBE2H UBL5 UBXN11 USP2 USP54 VEZF1 VGLL1 VIM VPS37B VPS37C YPEL3 YTHDF1 ZBTB16 ZBTB24 ZBTB47 ZFHX3 ZGPAT ZIC1 ZMYND12 ZNF330 ZNF34 ZNF383 ZNF408 ZNF414 ZNF417 ZNF467 ZNF48 ZNF503 ZNF524 ZNF576 ZNF688 ZNF792 ZNF835 ZRANB1	32 interacting genes: ABRAXAS2 ARIH1 ARIH2 ARRDC3 AURKB CALM1 CDIP1 CUL5 DAZAP2 DVL2 FAM168A GMPPA LAPTM5 LZTS2 MAP3K1 NEDD4 PLEKHB2 RHOA RNF11 SMAD2 SUSD6 TLE5 TMEM239 TP53BP2 TRIM39 TRIM54 TRIM8 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		166	54165
HPRD ID		02556	12067
Ensembl ID		ENSG00000104964	ENSG00000043093
Uniprot IDs		Q08117	B4DM76 C9JVE2 Q96GG9
PDB IDs			3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W 6XOL 6XOM 6XON 6XOO 6XOP 6XOQ 7KWA 8OR2 8OR3
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Intermediate Filament Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Metabolic Process Keratin Filament Identical Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Cellular Developmental Process Cell Differentiation Pattern Specification Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process NEDD8 Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Midbody NEDD8 Transferase Activity Ubiquitin Ligase Complex Cleavage Furrow Formation Mitotic Spindle Assembly Macromolecule Catabolic Process Protein Targeting To Vacuole Innate Immune Response Negative Regulation Of Signal Transduction Protein Polyubiquitination Transferase Activity Establishment Of Protein Localization To Vacuole Proteolysis Spindle Midzone Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Mitotic Cytokinesis Cytosol Intrinsic Apoptotic Signaling Pathway Vesicle Protein K63-linked Ubiquitination Cul5-RING Ubiquitin Ligase Complex Endosome Defense Response To Symbiont Negative Regulation Of CGAS/STING Signaling Pathway Defense Response To Other Organism Protein Binding Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Cytokinesis Ubiquitin-like Protein Transferase Activity Spindle Assembly Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Protein Localization To Vacuole Protein Neddylation
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