BRINP1 and SMPDL3A

Number of citations of the paper that reports this interaction (PubMedID 12442002)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		BRINP1	SMPDL3A
Description		BMP/retinoic acid inducible neural specific 1	sphingomyelin phosphodiesterase acid like 3A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite Neuronal Cell Body Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Protein Binding	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Metal Ion Binding
	Biological Process	Behavioral Fear Response Nervous System Development Brain Development Short-term Memory Cell Population Proliferation Gene Expression Proteasomal Protein Catabolic Process Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neurogenesis Social Behavior Exploration Behavior Maternal Behavior Positive Regulation Of Neuron Differentiation Negative Regulation Of Mitotic Cell Cycle Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Neurogenesis Protein Stabilization Regulation Of Cell Cycle Cellular Response To Retinoic Acid Vocalization Behavior	Sphingomyelin Catabolic Process Nucleoside Triphosphate Catabolic Process Negative Regulation Of CGAS/STING Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Coffee consumption ( 31046077) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) ghrelin levels ( 33852427) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Impulsivity (motor) ( 30718321) LDL cholesterol levels in HIV infection ( 33109212) Manganese levels ( 26025379) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels in HIV infection ( 33109212) Urinary sodium excretion ( 31409800)	Blood protein levels ( 30072576) Malaria ( 31844061)
Interacting Genes		5 interacting genes: CCND1 HDAC3 MDM2 RAC1 SMPDL3A	1 interacting genes: BRINP1
Entrez ID		1620	10924
HPRD ID		04181	10244
Ensembl ID		ENSG00000078725	ENSG00000172594
Uniprot IDs		O60477	Q92484
PDB IDs			5EBB 5EBE
Enriched GO Terms of Interacting Partners?		Transcription Repressor Complex Enzyme Binding Response To Magnesium Ion Response To Lipid Response To Steroid Hormone Response To Iron Ion Positive Regulation Of Protein Transport Response To Xenobiotic Stimulus Regulation Of Protein Export From Nucleus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Estrogen Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Transport Positive Regulation Of Protein Localization Response To Vitamin Regulation Of Mitotic Cell Cycle Response To Nutrient Levels Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Ferroptosis Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Phase Transition Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Response To Glucocorticoid Response To Hormone Regulation Of Nucleocytoplasmic Transport Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Protein De-2-hydroxyisobutyrylase Activity Positive Regulation Of Intracellular Transport Response To UV Response To Ionizing Radiation Response To Nutrient Signal Transduction In Response To DNA Damage Response To Corticosteroid Regulation Of G1/S Transition Of Mitotic Cell Cycle	Fear Response Short-term Memory Behavioral Fear Response Exploration Behavior Behavioral Defense Response Homeostasis Of Number Of Cells Within A Tissue Reproductive Behavior Vocalization Behavior Maternal Behavior Parental Behavior Central Nervous System Neuron Development Social Behavior Multicellular Organismal Response To Stress Cellular Response To Retinoic Acid Positive Regulation Of Neuron Differentiation Response To Retinoic Acid Neurogenesis Negative Regulation Of Nervous System Development Central Nervous System Neuron Differentiation Negative Regulation Of Neurogenesis Memory Anatomical Structure Homeostasis Tissue Homeostasis Neuron Development Regulation Of Neuron Differentiation Homeostasis Of Number Of Cells Negative Regulation Of Mitotic Cell Cycle Protein Stabilization Brain Development
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