CYP27B1 and TMEM50B

		CYP27B1	TMEM50B
Description		cytochrome P450 family 27 subfamily B member 1	transmembrane protein 50B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Monooxygenase Activity Calcidiol 1-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Secalciferol 1-monooxygenase Activity	Protein Binding
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Type II Interferon Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Biosynthetic Process Vitamin D Catabolic Process Response To Estrogen Small Molecule Biosynthetic Process Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Vitamin D	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Pathways		Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A
Drugs		Alfacalcidol
Diseases		Type I diabetes mellitus
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)	Crohn's disease ( 23128233) Educational attainment ( 25201988)
Interacting Genes		8 interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4	22 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 CYP27B1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35H1 TMEM14B TMEM52B TMEM88 TMX2
Entrez ID		1594	757
HPRD ID		02031	10747
Ensembl ID		ENSG00000111012	ENSG00000142188
Uniprot IDs		O15528	F8WDH1 P56557 Q2V8N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Abducens Nucleus Development Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Hypoglossal Nucleus Development H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Growth Plate Cartilage Chondrocyte Proliferation Cis-regulatory Region Sequence-specific DNA Binding Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Methionyl-tRNA Aminoacylation Methionine-tRNA Ligase Activity Establishment Of Meiotic Sister Chromatid Cohesion Stem Cell Population Maintenance Maintenance Of Cell Number RNA Uridylyltransferase Activity Polyuridylation-dependent MRNA Catabolic Process Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Immune Response In Gut-associated Lymphoid Tissue Transposable Element Silencing By MRNA Destabilization Meiotic Cohesin Complex Mediator Complex Binding Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Unconventional Myosin Complex Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Establishment Of Sister Chromatid Cohesion	Membrane Mitochondrial Membrane
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