CYP27B1 and ITGB7

		CYP27B1	ITGB7
Description		cytochrome P450 family 27 subfamily B member 1	integrin subunit beta 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome
	Molecular Function	Monooxygenase Activity Calcidiol 1-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Secalciferol 1-monooxygenase Activity	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Type II Interferon Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Biosynthetic Process Vitamin D Catabolic Process Response To Estrogen Small Molecule Biosynthetic Process Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Vitamin D	Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling T Cell Migration Cell-cell Adhesion
Pathways		Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs		Alfacalcidol	R1295 Vedolizumab Etrolizumab
Diseases		Type I diabetes mellitus
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)	Obesity-related traits ( 23251661) Type 1 diabetes ( 34127860)
Interacting Genes		8 interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4	17 interacting genes: CDH1 CYP27B1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1 ZBTB14
Entrez ID		1594	3695
HPRD ID		02031	00948
Ensembl ID		ENSG00000111012	ENSG00000139626
Uniprot IDs		O15528	P26010
PDB IDs			2BRQ 3V4P 3V4V 8ZJF
Enriched GO Terms of Interacting Partners?		Abducens Nucleus Development Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Hypoglossal Nucleus Development H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Growth Plate Cartilage Chondrocyte Proliferation Cis-regulatory Region Sequence-specific DNA Binding Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Methionyl-tRNA Aminoacylation Methionine-tRNA Ligase Activity Establishment Of Meiotic Sister Chromatid Cohesion Stem Cell Population Maintenance Maintenance Of Cell Number RNA Uridylyltransferase Activity Polyuridylation-dependent MRNA Catabolic Process Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Immune Response In Gut-associated Lymphoid Tissue Transposable Element Silencing By MRNA Destabilization Meiotic Cohesin Complex Mediator Complex Binding Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Unconventional Myosin Complex Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Establishment Of Sister Chromatid Cohesion	Cell-cell Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Regulation Of Cell Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Protein Kinase C Signaling Positive Regulation Of Protein Import Into Nucleus Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Integrin Binding Cell Migration Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Receptor Clustering Cell-cell Adhesion Mediated By Integrin Leukocyte Cell-cell Adhesion Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport B Cell Activation Cell Motility Perinuclear Region Of Cytoplasm Extracellular Exosome Regulation Of Protein Transport Integrin Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cellular Response To Insulin Stimulus Enzyme Activator Activity Positive Regulation Of Intracellular Protein Transport Cell Adhesion Molecule Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Plasma Membrane Protein Activation Cascade Positive Regulation Of Cell Motility Protein Localization To Membrane Cadherin Binding Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility
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