AKAP14 and PRKAR2B

Number of citations of the paper that reports this interaction (PubMedID 12475942)
45

Data Source:
HPRD (in vitro, in vivo)

		AKAP14	PRKAR2B
Description		A-kinase anchoring protein 14	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Axoneme CAMP-dependent Protein Kinase Complex	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase A Regulatory Subunit Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process		Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: DPY30 FBXO7 PRKACA PRKAR1B PRKAR2A PRKAR2B ROPN1 ROPN1L	25 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		158798	5577
HPRD ID		02353	01486
Ensembl ID		ENSG00000186471	ENSG00000005249
Uniprot IDs		Q86UN6	B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex Ciliary Base CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Sperm Capacitation CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Negative Regulation Of Intracellular Signal Transduction Nucleotide-activated Protein Kinase Complex Cell Maturation Developmental Maturation Motile Cilium Plasma Membrane Raft Protein Domain Specific Binding Postsynapse Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication G Protein-coupled Receptor Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Intracellular Signal Transduction Protein Kinase Binding Response To Antipsychotic Drug Modulation Of Chemical Synaptic Transmission Axoneme Lewy Body Core Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Cilium Glutamatergic Synapse Centrosome CAMP-dependent Protein Kinase Activity Cilium Movement Channel Activator Activity Regulation Of Macroautophagy Positive Regulation Of Fear Response CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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