MOSPD2 and STARD3

Number of citations of the paper that reports this interaction (PubMedID 33124732)
83

Data Source:
BioGRID (x-ray crystallography, pull down)

		MOSPD2	STARD3
Description		motile sperm domain containing 2	StAR related lipid transfer domain containing 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane Specific Granule Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-endosome Membrane Contact Site	Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Membrane Cytosol Membrane Late Endosome Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-endosome Membrane Contact Site
	Molecular Function	Protein Binding FFAT Motif Binding	Protein Binding Lipid Binding Cholesterol Binding Protein Homodimerization Activity Cholesterol Transfer Activity
	Biological Process	Chemotaxis Protein Homooligomerization Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Monocyte Chemotaxis Lipid Droplet Formation	Lipid Metabolic Process Progesterone Biosynthetic Process Mitochondrial Transport Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Small Molecule Metabolic Process Vesicle Tethering To Endoplasmic Reticulum
Pathways		Neutrophil degranulation RHOD GTPase cycle	Pregnenolone biosynthesis
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 28552196) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Waist-to-hip circumference ratio (dietary energy interaction) ( 23192594)	Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hemoglobin levels ( 32327693) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)
Interacting Genes		2 interacting genes: BTN1A1 STARD3	14 interacting genes: AQP6 CASC3 CLEC11A CREB3 DAPK1 GOPC LMNA MOSPD2 MYO1D RNF170 SCGB1A1 SLC39A7 VAPA VAPB
Entrez ID		158747	10948
HPRD ID		06642	06132
Ensembl ID		ENSG00000130150	ENSG00000131748
Uniprot IDs		Q8NHP6 R4GMN1	Q14849
PDB IDs		6TQS 6TQT 6TQU	1EM2 5I9J 6TQR 6TQU
Enriched GO Terms of Interacting Partners?		Vesicle Tethering To Endoplasmic Reticulum Endoplasmic Reticulum-endosome Membrane Contact Site Progesterone Biosynthetic Process Organelle Membrane Contact Site C21-steroid Hormone Biosynthetic Process Progesterone Metabolic Process Mitochondrial Transport Cholesterol Transfer Activity C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Hormone Biosynthetic Process Vesicle Tethering Ketone Biosynthetic Process Cholesterol Binding Cholesterol Transport	FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Endoplasmic Reticulum Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Monocyte Chemotaxis Intracellular Transport Viral Release From Host Cell Viral Process Endoplasmic Reticulum Exit Site Regulation Of Monocyte Chemotaxis Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Nitrate Transmembrane Transporter Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Localization Establishment Of Localization In Cell Polychlorinated Biphenyl Binding Endoplasmic Reticulum Positive Regulation Of Deacetylase Activity Negative Regulation Of Anion Channel Activity Endoplasmic Reticulum Organization Nuclear Membrane Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response Golgi Vesicle Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation By Virus Of Viral Protein Levels In Host Cell Host-mediated Perturbation Of Viral Process Sterol Transport Organelle Localization By Membrane Tethering Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Unfolded Protein Membrane Docking Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of NMDA Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Response To Ozone Response To Silicon Dioxide
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