STARD3 and CLEC11A

		STARD3	CLEC11A
Description		StAR related lipid transfer domain containing 3	C-type lectin domain containing 11A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Membrane Cytosol Membrane Late Endosome Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-endosome Membrane Contact Site	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Protein Homodimerization Activity Cholesterol Transfer Activity	Protein Binding Growth Factor Activity Carbohydrate Binding
	Biological Process	Lipid Metabolic Process Progesterone Biosynthetic Process Mitochondrial Transport Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Small Molecule Metabolic Process Vesicle Tethering To Endoplasmic Reticulum	Ossification Signal Transduction Positive Regulation Of Cell Population Proliferation
Pathways		Pregnenolone biosynthesis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hemoglobin levels ( 32327693) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)	Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Dietary fat liking ( 32516399) Stem cell growth factor beta levels ( 27989323) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		14 interacting genes: AQP6 CASC3 CLEC11A CREB3 DAPK1 GOPC LMNA MOSPD2 MYO1D RNF170 SCGB1A1 SLC39A7 VAPA VAPB	3 interacting genes: KITLG STARD3 UBQLN2
Entrez ID		10948	6320
HPRD ID		06132	05277
Ensembl ID		ENSG00000131748	ENSG00000105472
Uniprot IDs		Q14849	Q9Y240
PDB IDs		1EM2 5I9J 6TQR 6TQU
Enriched GO Terms of Interacting Partners?		FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Endoplasmic Reticulum Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Monocyte Chemotaxis Intracellular Transport Viral Release From Host Cell Viral Process Endoplasmic Reticulum Exit Site Regulation Of Monocyte Chemotaxis Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Nitrate Transmembrane Transporter Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Localization Establishment Of Localization In Cell Polychlorinated Biphenyl Binding Endoplasmic Reticulum Positive Regulation Of Deacetylase Activity Negative Regulation Of Anion Channel Activity Endoplasmic Reticulum Organization Nuclear Membrane Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response Golgi Vesicle Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation By Virus Of Viral Protein Levels In Host Cell Host-mediated Perturbation Of Viral Process Sterol Transport Organelle Localization By Membrane Tethering Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Unfolded Protein Membrane Docking Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of NMDA Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Response To Ozone Response To Silicon Dioxide	Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Regulation Of Mast Cell Apoptotic Process Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Vesicle Tethering To Endoplasmic Reticulum Endoplasmic Reticulum-endosome Membrane Contact Site Progesterone Biosynthetic Process Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Mast Cell Migration Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Organelle Membrane Contact Site C21-steroid Hormone Biosynthetic Process Myeloid Cell Apoptotic Process Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Developmental Pigmentation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Progesterone Metabolic Process Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Programmed Cell Death Involved In Cell Development Embryonic Hemopoiesis Negative Regulation Of Myeloid Cell Apoptotic Process Cholesterol Transfer Activity C21-steroid Hormone Metabolic Process Regulation Of ERAD Pathway Steroid Hormone Biosynthetic Process Vesicle Tethering Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Myeloid Cell Apoptotic Process Ketone Biosynthetic Process Epithelial Cell Migration Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Transport Hormone Biosynthetic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Leukocyte Apoptotic Process
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