AK8 and ALKBH3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AK8	ALKBH3
Description		adenylate kinase 8	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Axoneme Sperm Flagellum Cell Projection 9+2 Motile Cilium	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding AMP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity DCMP Kinase Activity	Protein Binding Ferrous Iron Binding Oxidoreductase Activity L-ascorbic Acid Binding Oxidative RNA Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity MRNA N1-methyladenosine Dioxygenase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Ventricular System Development Nucleoside Monophosphate Phosphorylation	DNA Repair DNA Alkylation Repair DNA Damage Response Cell Population Proliferation Negative Regulation Of Cytoplasmic Translation
Pathways		Interconversion of nucleotide di- and triphosphates	ALKBH3 mediated reversal of alkylation damage
Drugs		Bis(Adenosine)-5'-Pentaphosphate	Ascorbic acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Morning person ( 30696823)
Interacting Genes		18 interacting genes: ALKBH3 CCDC102B CDK18 CFTR CNTF DPY30 FBXO7 HAUS1 MAP3K7CL MCM7 MID1IP1 PRMT6 PRRC2B RBM39 SMG9 SYT17 UBE2Z ZMAT2	13 interacting genes: AK8 FBXO7 GLRX3 GOLGA2 GSK3A IKZF1 LNX1 OTUD4 SRPK1 SRPK2 TRIM55 TRIM63 ZDHHC17
Entrez ID		158067	221120
HPRD ID		12991	16793
Ensembl ID		ENSG00000165695	ENSG00000166199
Uniprot IDs		Q96MA6	Q96Q83
PDB IDs			2IUW 8JNK 8JNR 9NCZ
Enriched GO Terms of Interacting Partners?			Protein Modification Process Protein Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Transferase Activity Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Innate Immune Response Protein Modification By Small Protein Conjugation Cytoplasm Defense Response To Other Organism Immune System Process Defense Response To Symbiont Positive Regulation Of Viral Genome Replication Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Muscle System Process Regulation Of Neuron Apoptotic Process Ubiquitin-protein Transferase Activity Kinase Activity Response To Other Organism Positive Regulation Of Viral Process Identical Protein Binding Regulation Of Carbohydrate Catabolic Process Protein Polyubiquitination Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Viral Genome Replication Immune Response Negative Regulation Of Viral Process Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Microtubule Response To External Biotic Stimulus Protein Serine Kinase Activity Lewy Body Core Regulation Of Protein K48-linked Deubiquitination
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