PRAG1 and PSAP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)

		PRAG1	PSAP
Description		PEAK1 related, kinase-activating pseudokinase 1	prosaposin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Anchoring Junction	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding
	Biological Process	Regulation Of Cell Shape Regulation Of Notch Signaling Pathway Negative Regulation Of Neuron Projection Development Cell Migration Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell Motility	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane
Pathways		RND2 GTPase cycle	Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases			Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Processed meat consumption ( 32066663) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid stimulating hormone levels ( 32769997) TPE interval (resting) ( 32386560)	Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)
Interacting Genes		3 interacting genes: CHGB PSAP UBE3A	23 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1
Entrez ID		157285	5660
HPRD ID		19497	01460
Ensembl ID		ENSG00000275342	ENSG00000197746
Uniprot IDs		Q86YV5	P07602
PDB IDs		5VE6 8DGN	1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG
Enriched GO Terms of Interacting Partners?		Prostate Gland Growth Organ Growth Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Ganglioside GT1b Binding Ganglioside GM1 Binding Regulation Of Golgi Lumen Acidification Positive Regulation Of Cellular PH Reduction Positive Regulation Of Protein Localization To Lysosome Developmental Growth Glycolipid Transport Epithelial Cell Differentiation Involved In Prostate Gland Development Progesterone Receptor Signaling Pathway Ceramide Transport Androgen Receptor Signaling Pathway Postsynaptic Cytosol	Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly
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