CYP2C18 and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		CYP2C18	ECSIT
Description		cytochrome P450 family 2 subfamily C member 18	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Metal Ion Binding Linoleic Acid Epoxygenase Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Linoleic Acid Metabolic Process	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Xenobiotics	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs		N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to clopidogrel therapy ( 19706858 28207573) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 23093944) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		6 interacting genes: A2M APOE ECSIT KMT2E PSEN1 SDC2	61 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		1562	51295
HPRD ID		03085	12225
Ensembl ID		ENSG00000108242	ENSG00000130159
Uniprot IDs		P33260	Q9BQ95
PDB IDs		2CIK 2H6P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid Precursor Protein Metabolic Process Enzyme Binding Regulation Of Immune Response Regulation Of Innate Immune Response Extracellular Matrix Negative Regulation Of Phospholipid Efflux Maintenance Of Location Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Maintenance Of Location In Cell Positive Regulation Of Dendritic Spine Development Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Development Regulation Of Neuron Projection Development Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Core Promoter Binding PDZ Domain Binding Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Set3 Complex Rpd3L-Expanded Complex Blood Microparticle Memory Negative Regulation Of Neuron Projection Development Myeloid Leukocyte Activation Interleukin-8 Binding Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cell Projection Organization Blood Vessel Development Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Phospholipid Efflux	Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse
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