ECSIT and A2M

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		ECSIT	A2M
Description		ECSIT signaling integrator	alpha-2-macroglobulin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Immune System Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitochondrial Respiratory Chain Complex I Assembly Toll-like Receptor 4 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Refractive error ( 32231278)
Interacting Genes		61 interacting genes: A2M AIRIM AP1M2 APOE APP BFSP2 BLMH CDC37 CEP55 CNN1 CORO2B CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MARCHF2 MAST1 MKRN3 MRPL4 NDUFA13 NFKB1 NXF1 OGT PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		51295	2
HPRD ID		12225	00072
Ensembl ID		ENSG00000130159	ENSG00000175899
Uniprot IDs		Q9BQ95	P01023
PDB IDs			1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process Arachidonate Epoxygenase Activity Lipoprotein Particle Regulation Of MiRNA Metabolic Process Epoxygenase P450 Pathway NF-kappaB P50/p65 Complex Positive Regulation Of Protein Metabolic Process I-SMAD Binding Cellular Response To Interleukin-6 Cytoplasm Regulation Of Amyloid Fibril Formation Response To Interleukin-6 Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Astrocyte Activation Involved In Immune Response Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process Caffeine Oxidase Activity Magnesium Ion Binding Response To Virus Positive Regulation Of MiRNA Metabolic Process Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Regulation Of MiRNA Transcription Antiviral Innate Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Metabolic Process SMAD Protein Complex Neuronal Cell Body Protein Ubiquitination Oxidative Demethylation Retinoic Acid 4-hydroxylase Activity Heteromeric SMAD Protein Complex Cellular Response To Nicotine Protein Binding Innate Immune Response Cytosol Arachidonate Metabolic Process Omega-hydroxylase P450 Pathway Defense Response To Virus Defense Response To Tumor Cell Demethylation Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Glutamatergic Synapse	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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