CYP1A2 and CYP1A1

		CYP1A2	CYP1A1
Description		cytochrome P450 family 1 subfamily A member 2	cytochrome P450 family 1 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity	Catalytic Activity Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Monooxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Flavonoid 3'-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Metal Ion Binding Hsp90 Protein Binding Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Toxin Metabolic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Lung Development Methylation Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Aflatoxin Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidative Demethylation Cellular Response To Cadmium Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Liver Development Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Nematode Response To Herbicide Response To Toxic Substance Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Genistein Response To Immobilization Stress Xenobiotic Catabolic Process Vitamin D Metabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Nitric Oxide Metabolic Process Response To Arsenic-containing Substance Digestive Tract Development Tissue Remodeling Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Diphenyl Ether Response To Aroclor 1254 Response To 2,3,7,8-tetrachlorodibenzodioxine Response To 3-methylcholanthrene
Pathways		Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs	PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins
Drugs		Isoniazid alpha-Naphthoflavone Cannabidiol Diacerein Nabiximols	2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21357676 21876539 25288136 31959922) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 27863252 32888494) Serum albumin levels ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21357676 31046077 21876539 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 19430483 21909115 26390057 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 28739976 21909115 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189 30910378) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		4 interacting genes: ABHD16A CYB5A CYP1A1 POR	10 interacting genes: AKR7A3 CELF6 CEMIP CMTM5 COX5A CYB5A CYP1A2 FBXW5 VAMP4 ZNF189
Entrez ID		1544	1543
HPRD ID		00489	00148
Ensembl ID		ENSG00000140505	ENSG00000140465
Uniprot IDs		P05177	A0N0X8 E7EMT5 P04798
PDB IDs		2HI4	4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
Enriched GO Terms of Interacting Partners?		Flavonoid Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Heme Binding Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Xenobiotic Metabolic Process Flavonoid 3'-monooxygenase Activity Lipid Modification Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Arachidonate Monooxygenase Activity Response To Nutrient Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Modified Amino Acid Metabolic Process Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Response To Ketone Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Positive Regulation Of Steroid Hormone Biosynthetic Process Monoacylglycerol Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Lipid Catabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Response To Phenylpropanoid	Aflatoxin Metabolic Process Electron Transfer Activity Toxin Metabolic Process Secondary Metabolic Process Toxin Biosynthetic Process Heme Binding Cellular Respiration Demethylase Activity Caffeine Oxidase Activity Dibenzo-p-dioxin Metabolic Process Synaptic Vesicle To Endosome Fusion Presynaptic Endosome Membrane NADP+ Binding Toxin Catabolic Process Aflatoxin Catabolic Process Hyaluronan Biosynthetic Process Positive Regulation Of Protein Kinase C Activity
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