CYP1A2

Description		cytochrome P450 family 1 subfamily A member 2
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Toxin Metabolic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Lung Development Methylation Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Aflatoxin Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidative Demethylation Cellular Response To Cadmium Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process
Pathways		Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs
Drugs		Isoniazid alpha-Naphthoflavone Cannabidiol Diacerein Nabiximols
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21357676 21876539 25288136 31959922) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 27863252 32888494) Serum albumin levels ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Novel Interacting Genes		4 novel interacting genes: ABHD16A CYB5A CYP1A1 POR
Interacting Genes		4 interacting genes: ABHD16A CYB5A CYP1A1 POR
Entrez ID		1544
HPRD ID		00489
Ensembl ID		ENSG00000140505
Uniprot IDs		P05177
PDB IDs		2HI4
Enriched GO Terms of Interacting Partners?		Flavonoid Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Heme Binding Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Xenobiotic Metabolic Process Flavonoid 3'-monooxygenase Activity Lipid Modification Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Arachidonate Monooxygenase Activity Response To Nutrient Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Modified Amino Acid Metabolic Process Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Response To Ketone Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Positive Regulation Of Steroid Hormone Biosynthetic Process Monoacylglycerol Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Lipid Catabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Response To Phenylpropanoid
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