CYBA and NCF2

Number of citations of the paper that reports this interaction (PubMedID 11248021)
25

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		CYBA	NCF2
Description		cytochrome b-245 alpha chain	neutrophil cytosolic factor 2
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Xenobiotic Stimulus Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Positive Regulation Of Cell Growth Response To Nutrient Levels Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Establishment Of Localization In Cell Mucus Secretion Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Gamma Radiation Reactive Oxygen Species Metabolic Process Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To L-glutamine	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Superoxide Anion Generation Innate Immune Response Respiratory Burst
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)	Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 19838195 26502338 26606652 27399966 28714469 33272962) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		12 interacting genes: APPBP2 CPT1A CYBB MDFI NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		1535	4688
HPRD ID		01989	01991
Ensembl ID		ENSG00000051523	ENSG00000116701
Uniprot IDs		B4DT46 H3BNP7 P13498	A0A0S2Z457 A0A8V8TMB9 P19878
PDB IDs		1WLP 7U8G 7YXW 8GZ3 8KEI 8WEJ 8X2L	1E96 1HH8 1K4U 1OEY 1WM5 2DMO 8WEJ
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Phagolysosome Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Metabolic Process Cytoplasm Animal Organ Regeneration Electron Transfer Activity	NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Regulation Of Respiratory Burst Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Superoxide-generating NAD(P)H Oxidase Activity Leukocyte Aggregation Inflammatory Response Positive Regulation Of Cell Growth Reactive Oxygen Species Biosynthetic Process Calprotectin Complex Neutrophil Aggregation Regulation Of Innate Immune Response Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Growth Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Lamellipodium Organization Cellular Response To L-glutamine Phagolysosome Peptidyl-cysteine S-nitrosylation Regulation Of Lamellipodium Assembly Regulation Of Toll-like Receptor Signaling Pathway Defense Response Erythrocyte Enucleation Toll-like Receptor 4 Binding Positive Regulation Of Cell Projection Organization Innate Immune Response Arachidonate Binding Regulation Of Lamellipodium Organization Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Leukocyte Cell-cell Adhesion Regulation Of Cell Growth Electron Transfer Activity Regulation Of Immune System Process Autocrine Signaling Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Membrane Defense Response To Symbiont Superoxide-generating NADPH Oxidase Activator Activity Defense Response To Other Organism Protein Kinase Binding Response To Ketone Positive Regulation Of Defense Response Thioesterase Binding Chronic Inflammatory Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?