KLHL23 and BBS5

		KLHL23	BBS5
Description		kelch like family member 23	Bardet-Biedl syndrome 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Phosphatidylinositol-3-phosphate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Heart Looping Visual Perception Protein Transport Cell Projection Organization Melanosome Transport Motile Cilium Assembly Intracellular Transport Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Common carotid intima-media thickness in HIV infection ( 29206233) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 32888494)	Iris heterochromicity ( 30895295)
Interacting Genes		6 interacting genes: ANXA1 ANXA7 BBS5 BNIP3L CDKN1A TK1	15 interacting genes: CFAP210 COTL1 CRADD CTSK EIF4EBP3 HRH1 KLC3 KLHL23 KLHL41 ORM2 PRDM2 SLC6A15 TOM1 TOM1L2 UBR3
Entrez ID		151230	129880
HPRD ID		11320	10353
Ensembl ID		ENSG00000213160	ENSG00000163093
Uniprot IDs		Q8NBE8	A0A0S2Z626 Q8N3I7
PDB IDs			6XTB
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Calcium-dependent Phospholipid Binding Keratinocyte Differentiation Phosphatidylserine Binding Vesicle Membrane Calcium-dependent Protein Binding Positive Regulation Of Programmed Cell Death Epidermal Cell Differentiation PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Thymidine Kinase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of T-helper 2 Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Cell-matrix Adhesion DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Regulation Of Neutrophil Apoptotic Process Phospholipase A2 Inhibitor Activity Positive Regulation Of T-helper 1 Cell Differentiation Neutrophil Clearance Oncogene-induced Cell Senescence Stress-induced Premature Senescence Thymidine Metabolic Process BBSome
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