TLCD4 and FA2H

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	FA2H
Description		TLC domain containing 4	fatty acid 2-hydroxylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Fatty Acid 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity
	Biological Process	Lipid Homeostasis	Sebaceous Gland Cell Differentiation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Galactosylceramide Biosynthetic Process Lipid Biosynthetic Process Sphingolipid Biosynthetic Process Lipid Modification Central Nervous System Myelin Maintenance Peripheral Nervous System Myelin Maintenance Regulation Of Hair Cycle Plasma Membrane Raft Organization Ceramide Biosynthetic Process Establishment Of Skin Barrier Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			General cognitive ability ( 25383866) Pancreatic cancer ( 25086665) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		73 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MIR137HG MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	33 interacting genes: AQP6 ARMC12 ASGR2 CD79A CREB3 CREB3L1 DLG2 EBP ELOVL4 ERGIC3 ERLIN1 FAM209A FCER1G GPR152 GPR37 GPX8 LMNA MARCHF8 MSR1 PEX12 PGRMC2 RIC3 SAR1A SGPL1 SLC10A1 SLC10A6 SLC35H1 SYT2 TLCD4 TMEM14B TMEM41A TMX2 UBQLN4
Entrez ID		148534	79152
HPRD ID		08110	16873
Ensembl ID		ENSG00000152078	ENSG00000103089
Uniprot IDs		Q96MV1	Q7L5A8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity
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