PARP4 and TUBA3C

		PARP4	TUBA3C
Description		poly(ADP-ribose) polymerase family member 4	tubulin alpha 3c
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton
	Molecular Function	DNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	DNA Repair Inflammatory Response DNA Damage Response Response To Xenobiotic Stimulus Protein Modification Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs
Diseases
GWAS		Idiopathic intracranial hypertension ( 29608535) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)	Coronary artery aneurysm in Kawasaki disease ( 27171184) Fasting blood insulin (BMI interaction) ( 22581228) Joint mobility (Beighton score) ( 27182965)
Interacting Genes		5 interacting genes: CCT6A MVP RNF10 SMAD3 TUBA3C	15 interacting genes: DYNLL1 DYNLT1 EIF3FP2 FYN GRM7 MYC NMI PARP4 PFDN5 PXN SIAH1 TUBG1 UBC XPO4 YWHAQ
Entrez ID		143	7278
HPRD ID		09598	03958
Ensembl ID		ENSG00000102699	ENSG00000198033
Uniprot IDs		Q9UKK3	P0DPH7 Q1ZYQ1
PDB IDs		8SWY 8SWZ 8SX1 8SX2 9BW6 9BW7
Enriched GO Terms of Interacting Partners?		Regulation Of Telomerase RNA Localization To Cajal Body Microtubule WD40-repeat Domain Binding Regulation Of Establishment Of Protein Localization To Chromosome Protein Stabilization Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization To Telomere Sterol Response Element Binding Transdifferentiation Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Negative Regulation Of Osteoblast Proliferation Regulation Of Lung Blood Pressure Co-SMAD Binding Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nodal Signaling Pathway Transcription Cis-regulatory Region Binding Heteromeric SMAD Protein Complex Positive Regulation Of Extracellular Matrix Assembly Trophoblast Cell Migration Nuclear Mineralocorticoid Receptor Binding Primary MiRNA Processing Embryonic Foregut Morphogenesis Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Regulation Of Protein Stability DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Nuclear Glucocorticoid Receptor Binding I-SMAD Binding Negative Regulation Of Cytosolic Calcium Ion Concentration	Spindle Identical Protein Binding G Protein-coupled Glutamate Receptor Signaling Pathway Cytoplasm Spindle Microtubule Glutamate Receptor Signaling Pathway Regulation Of Cellular Localization Detection Of Mechanical Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Regulation Of Cell Communication Response To Singlet Oxygen Regulation Of Signaling Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding RNA Polymerase III Assembly RNA Polymerase I Assembly Microtubule Associated Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Transport Of Viral Material Towards Nucleus Positive Regulation Of Intracellular Transport Dynein Complex Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Substantia Nigra Development Cytosol Cytoplasmic Microtubule Protein Ubiquitination Modification-dependent Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Glycine Scaffold Protein Binding Regulation Of Transport Group III Metabotropic Glutamate Receptor Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Myc-Max Complex Regulation Of Acinar Cell Proliferation RNA Polymerase II Core Complex Assembly Regulation Of Intracellular Transport Intracellular Transport Of Viral Protein In Host Cell Microtubule Nucleator Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Neural Nucleus Development Response To Xenobiotic Stimulus T Cell Proliferation Protein Modification By Small Protein Conjugation Positive Regulation Of Establishment Of Protein Localization
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