TUBA3C and GRM7

Number of citations of the paper that reports this interaction (PubMedID 11953448)
40

Data Source:
HPRD (in vitro, in vivo)

		TUBA3C	GRM7
Description		tubulin alpha 3c	glutamate metabotropic receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton	Plasma Membrane Cell Cortex Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding Hydrolase Activity Metal Ion Binding	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Glutamate Binding PDZ Domain Binding Protein Dimerization Activity Serine Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic Axon Development Glycosylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			Glutamic acid
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 27171184) Fasting blood insulin (BMI interaction) ( 22581228) Joint mobility (Beighton score) ( 27182965)	Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cognitive function in longevity ( 33607172) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		15 interacting genes: DYNLL1 DYNLT1 EIF3FP2 FYN GRM7 MYC NMI PARP4 PFDN5 PXN SIAH1 TUBG1 UBC XPO4 YWHAQ	15 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 NGLY1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8
Entrez ID		7278	2917
HPRD ID		03958	04979
Ensembl ID		ENSG00000198033	ENSG00000196277
Uniprot IDs		P0DPH7 Q1ZYQ1	B2R693 B7ZKK0 B9EGG9 Q14831 Q59G95
PDB IDs			3MQ4 5C5C 7EPC 7EPD
Enriched GO Terms of Interacting Partners?		Spindle Identical Protein Binding G Protein-coupled Glutamate Receptor Signaling Pathway Cytoplasm Spindle Microtubule Glutamate Receptor Signaling Pathway Regulation Of Cellular Localization Detection Of Mechanical Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Regulation Of Cell Communication Response To Singlet Oxygen Regulation Of Signaling Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding RNA Polymerase III Assembly RNA Polymerase I Assembly Microtubule Associated Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Transport Of Viral Material Towards Nucleus Positive Regulation Of Intracellular Transport Dynein Complex Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Substantia Nigra Development Cytosol Cytoplasmic Microtubule Protein Ubiquitination Modification-dependent Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Glycine Scaffold Protein Binding Regulation Of Transport Group III Metabotropic Glutamate Receptor Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Myc-Max Complex Regulation Of Acinar Cell Proliferation RNA Polymerase II Core Complex Assembly Regulation Of Intracellular Transport Intracellular Transport Of Viral Protein In Host Cell Microtubule Nucleator Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Neural Nucleus Development Response To Xenobiotic Stimulus T Cell Proliferation Protein Modification By Small Protein Conjugation Positive Regulation Of Establishment Of Protein Localization	Cytoskeleton Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Structural Constituent Of Cytoskeleton Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Mitotic Cell Cycle Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling GTP Binding Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Microtubule Cytoskeleton Organization Calcineurin-mediated Signaling Presynaptic Cytosol Microtubule Cytoskeleton Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transporter Binding Spindle Microtubule Presynaptic Endocytosis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Substantia Nigra Development Microtubule Calcium Channel Regulator Activity Cytoskeleton Organization Sperm Midpiece Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Positive Regulation Of Sequestering Of Calcium Ion Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Negative Regulation Of Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Synaptic Plasticity
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