TRIM69 and IYD

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		TRIM69	IYD
Description		tripartite motif containing 69	iodotyrosine deiodinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Nucleoplasm Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding FMN Binding Oxidoreductase Activity Iodotyrosine Deiodinase Activity
	Biological Process	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome	Tyrosine Metabolic Process Thyroid Hormone Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Thyroxine biosynthesis
Drugs			3,5-Diiodotyrosine
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Anger ( 24489884)
Interacting Genes		55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	2 interacting genes: SYNE1 TRIM69
Entrez ID		140691	389434
HPRD ID		11518	16668
Ensembl ID		ENSG00000185880	ENSG00000009765
Uniprot IDs		H0YL66 Q86WT6	Q2VPV9 Q6PHW0
PDB IDs		4NQJ 6YXE	4TTB 4TTC 5YAK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization	Nuclear Matrix Organization Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Centrosome Separation Lamin Binding Maintenance Of Protein Location In Nucleus Protein Localization To Centrosome Nuclear Outer Membrane Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location In Cell Cytoskeleton Sarcomere Maintenance Of Protein Location Protein Localization To Cytoskeleton Centrosome Cycle Maintenance Of Location In Cell Nucleus Organization Maintenance Of Location Identical Protein Binding Microtubule Organizing Center Organization P-body Muscle Cell Differentiation
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