TRIM69 and ETFDH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM69	ETFDH
Description		tripartite motif containing 69	electron transfer flavoprotein dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Quinone Binding Ubiquinone Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Apoptotic Process Centrosome Cycle Protein Ubiquitination Innate Immune Response Centrosome Separation Protein Localization To Centrosome	Response To Oxidative Stress Electron Transport Chain Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Respiratory electron transport
Drugs			Metformin 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
Diseases			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Metabolic traits ( 21886157) Metabolite levels ( 20037589 31628463) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		55 interacting genes: APP ASNS ATP5MC1 BEX2 BIN3 CDSN DVL1 ETFDH EYA4 FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL SPMIP2 STK3 STK4 STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	9 interacting genes: CLCN3 GSC2 HSD17B10 KRTAP11-1 KRTAP13-2 MYH7B OTX1 TRIM69 ZNF581
Entrez ID		140691	2110
HPRD ID		11518	01978
Ensembl ID		ENSG00000185880	ENSG00000171503
Uniprot IDs		H0YL66 Q86WT6	B4DEQ0 Q16134
PDB IDs		4NQJ 6YXE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin Conjugating Enzyme Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity MRNA 3'-splice Site Recognition Innate Immune Response Protein Binding Regulation Of Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Protein Polyubiquitination Neural Tube Formation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Ubiquitination Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Defense Response To Symbiont Defense Response To Other Organism Wnt Signalosome Microtubule Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Ubiquitination Protein Monoubiquitination Protein Localization To Microtubule Supramolecular Fiber Organization Protein Stabilization	Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Diencephalon Morphogenesis Chloride:proton Antiporter Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Metencephalon Development Keratin Filament Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity Isoleucine Metabolic Process L-isoleucine Catabolic Process Mitochondrial RNA 5'-end Processing (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of CAMKK-AMPK Signaling Cascade Intermediate Filament Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Cardiac Myofibril Structural Molecule Activity DNA-binding Transcription Factor Activity TRNA 3'-end Processing
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