CRHR1 and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 23576434)
52

Data Source:
BioGRID (pull down)

		CRHR1	MAGI3
Description		corticotropin releasing hormone receptor 1	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding
	Biological Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Adrenal Gland Development Cellular Response To Hormone Stimulus Exploration Behavior Fear Response Behavioral Response To Ethanol Regulation Of Transport Corticotropin Secretion General Adaptation Syndrome, Behavioral Process Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Corticorelin ovine triflutate
Diseases
GWAS		A body shape index ( 34021172) Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Brain morphology (MOSTest) ( 32665545) Cerebral white matter volume ( 31530798) Cortical surface area (global PC1) ( 32198502) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Reticulocyte count ( 32888494) Schizophrenia ( 33169155) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		21 interacting genes: ARRB1 ARRB2 CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ ORMDL3 PDZK1 PTPN13 SRPK1 UCN UCN3	24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2
Entrez ID		1394	260425
HPRD ID		08830	11290
Ensembl ID		ENSG00000120088	ENSG00000081026
Uniprot IDs		B3SXS2 B3TIK8 G3CIS4 K9J956 P34998	Q5TCQ9
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G 6P9X 6PB0 8GTG 8GTI 8GTM	3SOE
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of System Process Regulation Of Transport Regulation Of Muscle System Process Guanyl Nucleotide Binding Corticotropin-releasing Hormone Receptor 2 Binding Adenylate Cyclase Regulator Activity G-protein Beta/gamma-subunit Complex Binding Plasma Membrane G Protein-coupled Receptor Binding D1 Dopamine Receptor Binding Heterotrimeric G-protein Complex Varicosity Regulation Of Peptide Hormone Secretion Bicellular Tight Junction Negative Regulation Of Transport Regulation Of Protein Localization Regulation Of Hormone Secretion Signal Transduction Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Mu-type Opioid Receptor Binding G Protein Activity Regulation Of Insulin Secretion Regulation Of Muscle Contraction Regulation Of Receptor Internalization G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Transport Beta-1 Adrenergic Receptor Binding G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Response To Prostaglandin E Positive Regulation Of Receptor Internalization Response To Ketone Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Ionotropic Glutamate Receptor Binding Cell Projection Regulation Of Monoatomic Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Postsynaptic Density Response To Alcohol Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase Activator Activity Regulation Of Protein Secretion Dendrite Desensitization Of G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission	Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway
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