ABRA and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 11983702)
0

Data Source:
HPRD (in vivo)

		ABRA	ACTC1
Description		actin binding Rho activating protein	actin alpha cardiac muscle 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Myofibril Sarcomere	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding
	Biological Process	Transcription By RNA Polymerase II Protein Import Into Nucleus Protein Transport Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration
Pathways			Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Dental caries ( 23259602) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Intraocular pressure ( 30054594 31959993) Metabolite levels ( 23823483)	Axial length ( 24144296) Refractive error ( 20835239 32231278)
Interacting Genes		6 interacting genes: ABLIM2 ACTA1 ACTB ACTC1 PPP1R18 TRAPPC2	43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		137735	70
HPRD ID		11608	00015
Ensembl ID		ENSG00000174429	ENSG00000159251
Uniprot IDs		Q8N0Z2	B3KPP5 P68032
PDB IDs			8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R
Enriched GO Terms of Interacting Partners?		Actin Filament Actin Cytoskeleton Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Blood Microparticle Lamellipodium Myosin Binding Sarcomere Filopodium Cell Body Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Structural Constituent Of Cytoskeleton Cytoskeleton Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body Cytoplasmic Actin-based Contraction Involved In Cell Motility Muscle Contraction Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Striated Muscle Thin Filament Muscle System Process Actin Filament Organization BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoplasm Brahma Complex Nitric-oxide Synthase Binding Apical Protein Localization RSC-type Complex Adherens Junction Assembly NpBAF Complex GBAF Complex Cellular Component Assembly Cardiac Myofibril Assembly TRAPPII Protein Complex TRAPP Complex TRAPPIII Protein Complex Organelle Organization NBAF Complex Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction	Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization
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