VPS37A and VPS28

Number of citations of the paper that reports this interaction (PubMedID 15240819)
44

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		VPS37A	VPS28
Description		VPS37A subunit of ESCRT-I	VPS28 subunit of ESCRT-I
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GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleoplasm Endosome Centrosome Cytosol Endosome Membrane Membrane Late Endosome Membrane	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Protein Transport Macroautophagy Negative Regulation Of Protein Ubiquitination Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Membrane Fission Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Schizophrenia ( 28991256) Tonometry ( 17903302)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		9 interacting genes: APP HGS KDM1A TRIM42 TRIM55 TRIM63 TSG101 UBC VPS28	49 interacting genes: ABI2 AKTIP ASF1A BEX2 BLZF1 CACNA1I CARD9 CBX5 CCDC146 CDK18 CEP57L1 CFTR COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SNCA SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52
Entrez ID		137492	51160
HPRD ID		13410	11675
Ensembl ID		ENSG00000155975	ENSG00000160948
Uniprot IDs		Q8NEZ2	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs		8E22	6VME
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Protein Metabolic Process Endosome Organization Protein Localization To Vacuole ESCRT I Complex Early Endosome Ubiquitin Binding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Budding Via Host ESCRT Complex Positive Regulation Of Endocytosis Macroautophagy Viral Budding Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Neuron Maturation Regulation Of Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Early Endosome Membrane Protein Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Transport Macromolecule Metabolic Process Endosomal Transport Protein Modification By Small Protein Conjugation Regulation Of Glycolytic Process Endosome Membrane Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Endosome Amylin Binding Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Endocytosis Vesicle Organization Autophagy	Viral Budding Via Host ESCRT Complex Viral Budding ESCRT I Complex Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Membrane Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagy Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Protein Localization To Vacuole Protein Binding Vacuolar Transport Endosomal Transport Membrane Fission Multivesicular Body Sorting Pathway Cytoplasm Identical Protein Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization To Vacuole Nucleus Viral Process Calcium-dependent Protein Binding Microtubule Binding Positive Regulation Of Exocytosis AMP-activated Protein Kinase Activity Regulation Of Extracellular Exosome Assembly Protein Transport Vesicle Organization Protein Kinase Inhibitor Activity Protein Targeting Regulation Of Protein Modification Process Nucleotide-activated Protein Kinase Complex SMN Complex Protein Targeting To Vacuole Protein-containing Complex Binding Gemini Of Cajal Bodies Positive Regulation Of Actin Nucleation Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Protein Tag Activity Organelle Assembly Establishment Of Localization In Cell Intracellular Protein Localization SMN-Sm Protein Complex
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