VPS28 and GLCCI1

Number of citations of the paper that reports this interaction (PubMedID 11591653)
29

Data Source:
HPRD (in vivo, in vitro)

		VPS28	GLCCI1
Description		VPS28 subunit of ESCRT-I	glucocorticoid induced 1
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Protein Transport Macroautophagy Negative Regulation Of Protein Ubiquitination Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Membrane Fission Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988)	Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 24684796) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340 28552196) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 23836780) Macular thickness ( 30535121) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		49 interacting genes: ABI2 AKTIP ASF1A BEX2 BLZF1 CACNA1I CARD9 CBX5 CCDC146 CDK18 CEP57L1 CFTR COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SNCA SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52	1 interacting genes: VPS28
Entrez ID		51160	113263
HPRD ID		11675	17043
Ensembl ID		ENSG00000160948	ENSG00000106415
Uniprot IDs		A0A0S2Z5H5 Q548N1 Q9UK41	Q86VQ1
PDB IDs		6VME
Enriched GO Terms of Interacting Partners?		Viral Budding Via Host ESCRT Complex Viral Budding ESCRT I Complex Multivesicular Body Organization Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Macroautophagy Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Membrane Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagy Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Protein Localization To Vacuole Protein Binding Vacuolar Transport Endosomal Transport Membrane Fission Multivesicular Body Sorting Pathway Cytoplasm Identical Protein Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization To Vacuole Nucleus Viral Process Calcium-dependent Protein Binding Microtubule Binding Positive Regulation Of Exocytosis AMP-activated Protein Kinase Activity Regulation Of Extracellular Exosome Assembly Protein Transport Vesicle Organization Protein Kinase Inhibitor Activity Protein Targeting Regulation Of Protein Modification Process Nucleotide-activated Protein Kinase Complex SMN Complex Protein Targeting To Vacuole Protein-containing Complex Binding Gemini Of Cajal Bodies Positive Regulation Of Actin Nucleation Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Protein Tag Activity Organelle Assembly Establishment Of Localization In Cell Intracellular Protein Localization SMN-Sm Protein Complex	Positive Regulation Of Ubiquitin-dependent Endocytosis Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Viral Budding ESCRT I Complex Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Negative Regulation Of Post-translational Protein Modification Protein Localization To Vacuole Endosome Organization Negative Regulation Of Protein Ubiquitination Ubiquitin Binding Positive Regulation Of Endocytosis Late Endosome Membrane Vacuolar Transport Macroautophagy Viral Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process
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