SPMIP4 and KLHL40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SPMIP4	KLHL40
Description		sperm microtubule inner protein 4	kelch like family member 40
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cilium Motile Cilium Cell Projection	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process		Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		11 interacting genes: APP BCL6 CLCNKA CLIC3 CYSRT1 HSF2BP KCTD9 KLHL40 OIP5 PFDN5 TEKT5	13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451
Entrez ID		136895	131377
HPRD ID		12919	11058
Ensembl ID		ENSG00000153790	ENSG00000157119
Uniprot IDs		Q8N865	A8K5H9 Q2TBA0
PDB IDs			4ASC
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Myeloid Cell Development Regulation Of Protein Import Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Regulation Of Amyloid Fibril Formation Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chloride Channel Complex Chloride Transmembrane Transport Chloride Channel Activity RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Protein-disulfide Reductase (glutathione) Activity Pericentric Heterochromatin Organization CENP-A Recruiting Complex	SUMO Ligase Activity
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