CRYBG3 and ARL6

		CRYBG3	ARL6
Description		crystallin beta-gamma domain containing 3	ARF like GTPase 6
Image		No pdb structure
GO Annotations	Cellular Component	Protein-containing Complex	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Carbohydrate Binding Protein Kinase A Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS			Male infertility ( 19478329)
Interacting Genes		2 interacting genes: ARL13B ARL6	12 interacting genes: ARL13B ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 CEBPD CRYBG3 GLS PROS1 SEC61B SYNRG
Entrez ID		131544	84100
HPRD ID		19091	10588
Ensembl ID		ENSG00000080200	ENSG00000113966
Uniprot IDs		Q68DQ2	Q9H0F7
PDB IDs			2H57
Enriched GO Terms of Interacting Partners?		Protein Localization To Non-motile Cilium Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Protein Localization To Cilium Axoneme Protein Transport From Ciliary Membrane To Plasma Membrane Cilium Organization GTPase Activity Protein Localization To Cell Periphery Cilium Assembly Microtubule Cytoskeleton Protein Localization To Membrane Receptor Localization To Non-motile Cilium Cell Projection Assembly GTP Binding Plasma Membrane Bounded Cell Projection Assembly Formation Of Radial Glial Scaffolds Pattern Specification Process Localization Within Membrane Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Cilium Protein Localization To Organelle Left/right Axis Specification Organelle Assembly Establishment Of Melanosome Localization Melanosome Localization Plasma Membrane Bounded Cell Projection Organization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Retina Layer Formation Membrane Coat Non-motile Cilium Axonemal Microtubule Cell Projection Organization Telencephalon Cell Migration Cell Projection Forebrain Cell Migration Non-motile Cilium Assembly Ciliary Membrane Establishment Of Protein Localization To Plasma Membrane Cytoskeleton Heart Looping Protein Targeting To Membrane Cellular Localization Dorsal/ventral Pattern Formation Embryonic Heart Tube Morphogenesis Protein Polymerization	Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport
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