COPB1 and TAPBP

Number of citations of the paper that reports this interaction (PubMedID 11884415)
0

Data Source:
HPRD (in vitro, in vivo)

		COPB1	TAPBP
Description		coat protein complex I subunit beta 1	TAP binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Tapasin-ERp57 Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding MHC Class I Protein Complex Binding MHC Class I Protein Binding Peptide Antigen Binding Protein Folding Chaperone TAP1 Binding TAP2 Binding Unfolded Protein Binding Molecular Adaptor Activity TAP Complex Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	MHC Class Ib Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Gene Expression Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Antigen Stabilization Regulation Of Protein Complex Stability Protein-containing Complex Assembly
Pathways		Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type1
GWAS		HDL cholesterol ( 26780889) HDL cholesterol levels ( 28334899 32203549) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576)
Interacting Genes		46 interacting genes: ADAM19 ANO1 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 DSCR9 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ RNF10 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6	10 interacting genes: CALR COPB1 COPG1 COPG2 HLA-A HLA-C TAP1 TAP2 TNF UBC
Entrez ID		1315	6892
HPRD ID		02981	09061
Ensembl ID		ENSG00000129083	ENSG00000231925
Uniprot IDs		P53618	A0A024RCT1 A0A0A0MSV9 A0A0A0MT98 A0A8V8TQC5 O15533
PDB IDs			3F8U 6ENY 7QNG 7QPD 7TUE 7TUF 7TUG
Enriched GO Terms of Interacting Partners?		COPI-coated Vesicle Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI Vesicle Coat COPI-coated Vesicle Transport Vesicle Golgi Vesicle Transport Vesicle-mediated Transport Golgi Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Reactive Oxygen Species Metabolic Process Golgi Apparatus Regulation Of Actin Cytoskeleton Organization Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Actin Filament-based Process Endoplasmic Reticulum-Golgi Intermediate Compartment Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Cytoskeleton Organization Endoplasmic Reticulum Membrane Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Negative Regulation Of Organ Growth Intra-Golgi Vesicle-mediated Transport Peptide Antigen Binding Regulation Of Protein Metabolic Process Plasma Membrane Regulation Of Innate Immune Response Signaling Receptor Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Projection Organization Cytoplasm Positive Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cytokine Production Regulation Of Cellular Component Organization Membrane Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Cellular Localization Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Intracellular Protein Transport ER To Golgi Transport Vesicle Membrane Positive Regulation Of Tolerance Induction	MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen COPI Vesicle Coat Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib COPI-coated Vesicle Membrane Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex Membrane Coat Lumenal Side Of Endoplasmic Reticulum Membrane Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Intra-Golgi Vesicle-mediated Transport Positive Regulation Of T Cell Mediated Cytotoxicity TAP Binding ABC-type Peptide Transporter Activity TAP1 Binding Regulation Of T Cell Mediated Cytotoxicity Cytosol To Endoplasmic Reticulum Transport Regulation Of Lymphocyte Mediated Immunity Endoplasmic Reticulum Cellular Localization Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains MHC Class Ib Protein Binding Regulation Of Adaptive Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity MHC Protein Binding Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Protein Transport Intracellular Protein Localization MHC Class I Protein Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Positive Regulation Of Immune Effector Process Golgi Membrane Intracellular Transport Adaptive Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
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