USP43 and CNTROB

		USP43	CNTROB
Description		ubiquitin specific peptidase 43	centrobin, centriole duplication and spindle assembly protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Basal Body
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity ISG15-specific Peptidase Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Proteolysis Protein Deubiquitination Translesion Synthesis	Centriole Replication Centrosome Separation Cell Division Regulation Of Cilium Assembly Mitotic Cytokinetic Process
Pathways		Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Refractive error ( 32231278)
Interacting Genes		4 interacting genes: CNTROB H2BC3 HDAC1 YWHAE	23 interacting genes: APTX COASY CWF19L2 DAPK1 DUSP29 ELOA EPM2AIP1 GSK3A HPCAL4 KRABD2 LYST MCRS1 PELI1 PNKP RAD23A RSPH14 SMARCA2 SYT6 TCEA2 TSC1 TSHZ2 TTC23 USP43
Entrez ID		124739	116840
HPRD ID		18926	13991
Ensembl ID		ENSG00000154914	ENSG00000170037
Uniprot IDs		Q70EL4	Q8N137
PDB IDs
Enriched GO Terms of Interacting Partners?		Hair Follicle Placode Formation Krueppel-associated Box Domain Binding Histone Deacetylase Binding Hippocampus Development Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Protein Domain Specific Binding Regulation Of Heart Rate By Hormone Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Heterodimerization Activity Negative Regulation Of Myotube Differentiation Enzyme Binding Host-mediated Suppression Of Viral Transcription Histone Deacetylase Activity Eyelid Development In Camera-type Eye Sin3-type Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation NuRD Complex Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Oligodendrocyte Differentiation Membrane Repolarization During Action Potential Protein Localization To Endoplasmic Reticulum Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Hippo Signaling Calcium Channel Inhibitor Activity Intracellular Potassium Ion Homeostasis Centrosome Separation	Polynucleotide 3'-phosphatase Activity DNA Metabolic Process DNA Repair Positive Regulation Of DNA Repair Damaged DNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair DNA Damage Response Positive Regulation Of DNA Metabolic Process Cellular Response To Stress DAPK1-calmodulin Complex Macromolecule Metabolic Process Positive Regulation Of Autophagic Cell Death Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Glycogen Metabolic Process Regulation Of TOR Signaling Regulation Of Glycogen Biosynthetic Process Response To Insulin Regulation Of Double-strand Break Repair Memory T Cell Differentiation DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Pantetheine-phosphate Adenylyltransferase Activity
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