FRMD6 and JMJD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FRMD6	JMJD6
Description		FERM domain containing 6	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Apical Junction Complex Cytoplasmic Side Of Apical Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity
	Biological Process	Apical Constriction Intracellular Protein Localization Regulation Of Actin Filament-based Process Positive Regulation Of Hippo Signaling	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly
Pathways			HDMs demethylate histones Protein hydroxylation
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		27 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MAK16 MED4 MID2 MLH1 NKAPD1 PARD6B RASSF8 SSX2IP SUV39H1 SYT17 TCF12 TLK2 TRIM55 TRIM63 TSC22D4 WDR7 YWHAB	31 interacting genes: AEBP2 ANKEF1 BAG5 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		122786	23210
HPRD ID		12646	05371
Ensembl ID		ENSG00000139926	ENSG00000070495
Uniprot IDs		Q96NE9	B2WTI3 B2WTI4 Q6NYC1
PDB IDs			3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?			Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus
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