ADD2 and RPH3A

Number of citations of the paper that reports this interaction (PubMedID 7707875)
0

Data Source:
HPRD (in vitro)

		ADD2	RPH3A
Description		adducin 2	rabphilin 3A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane F-actin Capping Protein Complex Postsynaptic Density Membrane Cytoplasmic Vesicle Plasma Membrane Raft	Plasma Membrane Synaptic Vesicle Membrane Extrinsic Component Of Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Cytoskeletal Anchor Activity Protein Kinase Binding Spectrin Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity Actin Filament Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Lipid Binding Selenium Binding Small GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Synapse Assembly Actin Cytoskeleton Organization Hemopoiesis Leukocyte Migration Leukocyte Tethering Or Rolling Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Protein-containing Complex Assembly	Intracellular Protein Transport Protein Transport Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Miscellaneous transport and binding events
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Response to esketamine in treatment resistant depression ( 32724131)	Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Epilepsy ( 33913524) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010 32154731) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Serum uric acid levels ( 32514006) Spleen volume ( 34128465) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: ADD1 APP BRWD1 CALM1 FYN PRKACA PRKCD PTPRZ1 RPH3A	14 interacting genes: ADD2 CASK CFAP298 GCH1 IFT81 MYO5A NRXN1 RAB15 RAB27A RAB27B RAB3A RAB3B RAB8A YWHAH
Entrez ID		119	22895
HPRD ID		00037	15273
Ensembl ID		ENSG00000075340	ENSG00000089169
Uniprot IDs		P35612 Q05DK5	Q9Y2J0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Calcium-mediated Signaling Regulation Of Dendritic Spine Maintenance Regulation Of Metal Ion Transport Regulation Of Biological Quality Regulation Of Superoxide Anion Generation Regulation Of Monoatomic Ion Transport Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Transport Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Localization To Nucleus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Fc Receptor Mediated Stimulatory Signaling Pathway Modulation Of Chemical Synaptic Transmission Calcium-mediated Signaling Calcium Channel Complex Cellular Response To Peptide Hormone Stimulus Ephrin Receptor Binding Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Metabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Fc-gamma Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Motile Cilium Cell Projection Neuron Projection Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Transport Membrane Regulation Of Neuron Apoptotic Process Regulation Of Blood Circulation Negative Regulation Of Actin Filament Polymerization Glutamate Receptor Signaling Pathway Learning Or Memory Perinuclear Region Of Cytoplasm Neuron Projection Morphogenesis Cellular Response To Amyloid-beta Sperm Midpiece Cell Projection Morphogenesis	Myosin V Binding GTPase Activity GTP Binding Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Intracellular Protein Localization Establishment Of Protein Localization Vesicle GDP Binding Protein Transport Establishment Of Localization In Cell Positive Regulation Of Exocytosis Nucleotide Binding Vesicle Localization Regulation Of Vesicle-mediated Transport Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Protein Localization To Synapse Vesicle-mediated Transport Organelle Localization G Protein Activity Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Protein Localization To Cell Junction Synaptic Vesicle Clustering Vesicle-mediated Transport In Synapse Melanosome Secretory Granule Positive Regulation Of Secretion By Cell Establishment Of Vesicle Localization Trans-Golgi Network Transport Vesicle Positive Regulation Of Secretion Hydrolase Activity GTP-dependent Protein Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Synaptic Vesicle Membrane Synaptic Vesicle Melanosome Localization Pigment Granule Localization Exocytic Vesicle Endosome Multivesicular Body Membrane Late Endosome
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