RPH3A and RAB3A

Number of citations of the paper that reports this interaction (PubMedID 12937130)
26

Data Source:
HPRD (in vitro, in vivo)

		RPH3A	RAB3A
Description		rabphilin 3A	RAB3A, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Extrinsic Component Of Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Extrinsic Component Of Synaptic Vesicle Membrane	Acrosomal Vesicle Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Transport Vesicle Axon Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cell Projection Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse Postsynapse Extracellular Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Lipid Binding Selenium Binding Small GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein-macromolecule Adaptor Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Protein Transport Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Plasma Membrane Repair Respiratory System Process Exocytosis Mitochondrion Organization Neuromuscular Synaptic Transmission Axonogenesis Post-embryonic Development Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Synaptic Vesicle Recycling Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Establishment Of Localization In Cell Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Clustering Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Epilepsy ( 33913524) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010 32154731) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Serum uric acid levels ( 32514006) Spleen volume ( 34128465) Urate levels ( 31578528)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		14 interacting genes: ADD2 CASK CFAP298 GCH1 IFT81 MYO5A NRXN1 RAB15 RAB27A RAB27B RAB3A RAB3B RAB8A YWHAH	32 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR GRSF1 KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF REP15 RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SNCA SYTL4 SYTL5 VRTN
Entrez ID		22895	5864
HPRD ID		15273	01535
Ensembl ID		ENSG00000089169	ENSG00000105649
Uniprot IDs		Q9Y2J0	A0A024R7I7 P20336
PDB IDs
Enriched GO Terms of Interacting Partners?		Myosin V Binding GTPase Activity GTP Binding Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Intracellular Protein Localization Establishment Of Protein Localization Vesicle GDP Binding Protein Transport Establishment Of Localization In Cell Positive Regulation Of Exocytosis Nucleotide Binding Vesicle Localization Regulation Of Vesicle-mediated Transport Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Protein Localization To Synapse Vesicle-mediated Transport Organelle Localization G Protein Activity Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Protein Localization To Cell Junction Synaptic Vesicle Clustering Vesicle-mediated Transport In Synapse Melanosome Secretory Granule Positive Regulation Of Secretion By Cell Establishment Of Vesicle Localization Trans-Golgi Network Transport Vesicle Positive Regulation Of Secretion Hydrolase Activity GTP-dependent Protein Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Synaptic Vesicle Membrane Synaptic Vesicle Melanosome Localization Pigment Granule Localization Exocytic Vesicle Endosome Multivesicular Body Membrane Late Endosome	Small GTPase Binding Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Localization Rab-protein Geranylgeranyltransferase Complex Synaptic Vesicle Priming Regulation Of Exocytosis Protein Geranylgeranylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Synapse Intracellular Protein Transport Protein Prenylation Secretion By Cell Neurexin Family Protein Binding Exocytosis Modulation Of Excitatory Postsynaptic Potential Cytoplasmic Vesicle Secretion Regulation Of Regulated Secretory Pathway Synaptic Vesicle Positive Regulation Of Vesicle Fusion Neuronal Dense Core Vesicle Signal Release Positive Regulation Of Exocytosis Astrocyte Activation Involved In Immune Response Rab Geranylgeranyltransferase Activity Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Neurotransmitter Transport Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Neurotransmitter Secretion Regulation Of Nervous System Process Regulation Of Secretion By Cell Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Synapse Organization Regulation Of Synaptic Vesicle Exocytosis Presynaptic Membrane Cellular Response To Amyloid-beta
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