ANTXR2 and FRAS1

		ANTXR2	FRAS1
Description		ANTXR cell adhesion molecule 2	Fraser extracellular matrix complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane	Basement Membrane Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding
	Biological Process	Single Fertilization Collagen Fibril Organization Uterus Development	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Anatomical Structure Morphogenesis Protein Transport Embryonic Limb Morphogenesis Skin Development Animal Organ Development System Development Roof Of Mouth Development
Pathways
Drugs		MDX-1303
Diseases		Infantile systemic hyalinosis and juvenile hyaline fibromatosis	Fraser syndrome
GWAS		Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 27863252 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)
Interacting Genes		12 interacting genes: CFTR COL4A2 COL4A3 COL4A4 COL4A5 DDX10 FRAS1 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2	4 interacting genes: ANTXR2 KLHL2 NAA11 PAQR3
Entrez ID		118429	80144
HPRD ID		07452	06382
Ensembl ID		ENSG00000163297	ENSG00000138759
Uniprot IDs		A4FUA5 J3KPY9 P58335 Q32Q26	Q86XX4
PDB IDs		1SHT 1SHU 1T6B 1TZN 7N1O 8FT6 8FT8 8FZ4 8FZU 8FZV 9DOC
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Structural Constituent Collagen Type IV Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Laminin-1 Complex Laminin-10 Complex Regulation Of Basement Membrane Organization Protein Complex Involved In Cell-matrix Adhesion Extracellular Structure Organization Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Integrin-mediated Signaling Pathway Response To Cholesterol Developmental Process Extracellular Region Endoderm Development Endodermal Cell Differentiation Animal Organ Morphogenesis Substrate Adhesion-dependent Cell Spreading Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Alcohol Laminin-8 Complex Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration CAAX-box Protein Maturation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Transforming Growth Factor Beta Positive Regulation Of Anion Channel Activity Laminin-2 Complex Positive Regulation Of Muscle Cell Differentiation Roof Of Mouth Development Homomeric SMAD Protein Complex Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Odontogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Monoatomic Anion Transport Regulation Of Epithelial Cell Proliferation Laminin-11 Complex Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis	Ubiquitin-like Ligase-substrate Adaptor Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Positive Regulation Of SREBP Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Maturation Regulation Of SREBP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Peroxisome Proliferator Activated Receptor Signaling Pathway
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