CIB3 and ARMC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIB3	ARMC8
Description		calcium and integrin binding family member 3	armadillo repeat containing 8
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GO Annotations	Cellular Component		Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol GID Complex Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Calcium Ion Homeostasis	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neutrophil degranulation Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494)	A body shape index ( 34021172) Mean spheric corpuscular volume ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		53 interacting genes: ARMC8 BEND7 C17orf50 ENOX2 GMCL1 KASH5 KLF17 LNX1 MEOX1 MEOX2 NANOS3 NME4 PAX5 PAX6 POLR2G POU6F2 RBAK REL SCNM1 SERTAD1 SLPI SP3 SP4 SYPL1 TACC3 TLE5 TRAF5 TRIM14 TRIM2 ZBTB43 ZC2HC1C ZFP1 ZFP57 ZNF146 ZNF177 ZNF180 ZNF19 ZNF276 ZNF317 ZNF329 ZNF398 ZNF426 ZNF552 ZNF559-ZNF177 ZNF578 ZNF597 ZNF620 ZNF664 ZNF688 ZNF774 ZNF835 ZSCAN4 ZSCAN5A	10 interacting genes: CIB3 CTNNA1 GID8 PKP1 PKP2 STX6 TCF12 TNNT1 USP25 ZMYND12
Entrez ID		117286	25852
HPRD ID		16713	09992
Ensembl ID		ENSG00000141977	ENSG00000114098
Uniprot IDs		Q96Q77	B7Z637 Q8IUR7
PDB IDs		6WU5 6WU7 6WUD	7NSC
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Binding DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding HMG Box Domain Binding Embryonic Camera-type Eye Morphogenesis Segment Specification Somite Development Chromatin	Intermediate Filament Binding Intermediate Filament Bundle Assembly Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Cell-cell Junction Organization Desmosome Adherens Junction Cell Junction Intercalated Disc Cell Junction Assembly Cornified Envelope Maintenance Of Protein Localization At Cell Tip Slow-twitch Skeletal Muscle Fiber Contraction Cadherin Binding Intermediate Filament Organization Desmosome Maintenance Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Anchoring Junction Negative Regulation Of Integrin-mediated Signaling Pathway Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Synaptic Vesicle To Endosome Fusion Negative Regulation Of Interleukin-17-mediated Signaling Pathway Cell Junction Organization Maintenance Of Animal Organ Identity Troponin T Binding Cell-cell Adhesion Cellular Response To Indole-3-methanol Transepithelial Water Transport Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Ubiquitin-like Protein Peptidase Activity Response To Indole-3-methanol Positive Regulation Of Cytoplasmic Translational Initiation Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Interleukin-17A-mediated Signaling Pathway Apical Junction Assembly Gap Junction Assembly Zonula Adherens Nuclear Stress Granule Intermediate Filament Ameloblast Differentiation Regulation Of Muscle Contraction Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Response To Gonadotropin-releasing Hormone Troponin Complex Transition Between Fast And Slow Fiber Negative Regulation Of ERAD Pathway
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