ZNF689 and NCL

Number of citations of the paper that reports this interaction (PubMedID 16568080)
0

Data Source:
HPRD (in vivo)

		ZNF689	NCL
Description		zinc finger protein 689	nucleolin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cornified Envelope Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cytoplasm Plasma Membrane Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Macropinosome Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Telomeric DNA Binding PH Domain Binding Identical Protein Binding Insulin Receptor Substrate Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation	Angiogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor
Pathways		Generic Transcription Pathway	Major pathway of rRNA processing in the nucleolus and cytosol Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)
Interacting Genes		6 interacting genes: HNRNPF HNRNPU NCL PRRT2 TMEM219 TRIM28	61 interacting genes: ADAP1 ADAP2 BCL2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DANCR DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R ISG15 LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 RNF10 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689
Entrez ID		115509	4691
HPRD ID		14009	01245
Ensembl ID		ENSG00000156853	ENSG00000115053
Uniprot IDs		Q96CS4	B3KM80 P19338
PDB IDs			2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex Regulation Of RNA Splicing Ribonucleoprotein Complex Single-stranded RNA Binding Catalytic Step 2 Spliceosome Cellular Response To Leukemia Inhibitory Factor Inactive Sex Chromosome Poly(C) RNA Binding Promoter-specific Chromatin Binding Cytoplasmic Ribonucleoprotein Granule RNA Localization To Chromatin Response To Leukemia Inhibitory Factor Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Spindle Microtubule Macropinosome Membrane Krueppel-associated Box Domain Binding Negative Regulation Of Short-term Synaptic Potentiation Negative Regulation Of SNARE Complex Assembly Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion RNA Binding TFIIH-class Transcription Factor Complex Binding Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of MRNA Processing Heterochromatin Formation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity RNA Polymerase II Transcription Regulator Complex Ubiquitin-like Protein Ligase Activity Negative Regulation Of Gene Expression, Epigenetic DNA Topoisomerase Binding Embryonic Placenta Morphogenesis Negative Regulation Of Vesicle Fusion MRNA Splicing, Via Spliceosome Transcription Corepressor Activity CRD-mediated MRNA Stability Complex Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding RNA Splicing, Via Transesterification Reactions PiRNA Binding RNA Polymerase II C-terminal Domain Binding Poly(G) Binding Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore PH Domain Binding Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone CRD-mediated MRNA Stabilization Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Epigenetic Regulation Of Gene Expression Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Vesicle Fusion To Plasma Membrane	Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Response To Stress Chromatin Organization Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Chromosome DNA Damage Response Regulation Of Cell Population Proliferation Cellular Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Protein Localization To Organelle DNA Binding Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Chromatin Remodeling Response To Gamma Radiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Gene Expression DNA Repair Negative Regulation Of DNA Metabolic Process Macromolecule Metabolic Process
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