ZNF689 and HNRNPU

Number of citations of the paper that reports this interaction (PubMedID 16568080)
0

Data Source:
HPRD (in vivo)

		ZNF689	HNRNPU
Description		zinc finger protein 689	heterogeneous nuclear ribonucleoprotein U
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Telomerase Holoenzyme Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell Surface Membrane Nuclear Matrix Nuclear Speck Dendrite Midbody Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding PiRNA Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing MRNA Processing Regulation Of Mitotic Cell Cycle RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cell Differentiation Erythrocyte Differentiation Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Rhythmic Process Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development Random Inactivation Of X Chromosome CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation Positive Regulation Of Cytoplasmic Translation
Pathways		Generic Transcription Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)
Interacting Genes		6 interacting genes: HNRNPF HNRNPU NCL PRRT2 TMEM219 TRIM28	42 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CEBPA CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HMGB1 HNRNPH3 HSPB1 IL7R KAT2B LINC00624 NDN NDRG1 NEDD4 NR3C1 NRON PIN1 PLK1 POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689
Entrez ID		115509	3192
HPRD ID		14009	04185
Ensembl ID		ENSG00000156853	ENSG00000153187
Uniprot IDs		Q96CS4	Q00839 Q96BA7
PDB IDs
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex Regulation Of RNA Splicing Ribonucleoprotein Complex Single-stranded RNA Binding Catalytic Step 2 Spliceosome Cellular Response To Leukemia Inhibitory Factor Inactive Sex Chromosome Poly(C) RNA Binding Promoter-specific Chromatin Binding Cytoplasmic Ribonucleoprotein Granule RNA Localization To Chromatin Response To Leukemia Inhibitory Factor Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Spindle Microtubule Macropinosome Membrane Krueppel-associated Box Domain Binding Negative Regulation Of Short-term Synaptic Potentiation Negative Regulation Of SNARE Complex Assembly Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion RNA Binding TFIIH-class Transcription Factor Complex Binding Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of MRNA Processing Heterochromatin Formation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity RNA Polymerase II Transcription Regulator Complex Ubiquitin-like Protein Ligase Activity Negative Regulation Of Gene Expression, Epigenetic DNA Topoisomerase Binding Embryonic Placenta Morphogenesis Negative Regulation Of Vesicle Fusion MRNA Splicing, Via Spliceosome Transcription Corepressor Activity CRD-mediated MRNA Stability Complex Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding RNA Splicing, Via Transesterification Reactions PiRNA Binding RNA Polymerase II C-terminal Domain Binding Poly(G) Binding Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore PH Domain Binding Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone CRD-mediated MRNA Stabilization Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Epigenetic Regulation Of Gene Expression Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Vesicle Fusion To Plasma Membrane	Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Postsynaptic Cytosol Developmental Process RNA Binding Protein-containing Complex Cellular Response To Stress Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Neurotrophin TRK Receptor Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Hemopoiesis Signal Transduction Negative Regulation Of Metabolic Process Response To Amino Acid
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