C1QTNF5 and NLRX1

		C1QTNF5	NLRX1
Description		C1q and TNF related 5	NLR family member X1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Lateral Plasma Membrane Transport Vesicle Protein-containing Complex Cell Projection	Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Protein Secretion Inner Ear Development	Immune System Process Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lifespan ( 25918517)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: GUCA1A MFRP NLRX1 SGTA SGTB SLC2A4	9 interacting genes: ABCG4 BUD13 C1QTNF5 IFT46 NHERF4 SARM1 SCN3B TMEM25 TMPRSS4
Entrez ID		114902	79671
HPRD ID		10575	17640
Ensembl ID		ENSG00000223953	ENSG00000160703
Uniprot IDs		Q9BXJ0	A0A9L9PX86 Q86UT6
PDB IDs		4F3J 4NN0	3UN9
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Guanylate Cyclase Activity Protein Targeting To Membrane Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Guanylate Cyclase Regulator Activity Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of CGMP-mediated Signaling Calcium Sensitive Guanylate Cyclase Activator Activity Visual Perception Sensory Perception Of Light Stimulus Nervous System Process Cone Photoreceptor Outer Segment Establishment Of Protein Localization To Membrane Protein Targeting BAT3 Complex Binding Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Negative Regulation Of RIG-I Signaling Pathway Dehydroascorbic Acid Transport Fat Cell Proliferation D-glucose Transmembrane Transporter Activity Membrane Short-term Memory Negative Regulation Of Macrophage Cytokine Production Regulation Of CGMP-mediated Signaling Negative Regulation Of Interferon-beta Production Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Trans-Golgi Network Transport Vesicle	NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Negative Regulation Of Growth Rate Guanylate Cyclase Inhibitor Activity RES Complex Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process ABC-type Sterol Transporter Activity
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