PWWP2A and HAVCR2

		PWWP2A	HAVCR2
Description		PWWP domain containing 2A	hepatitis A virus cellular receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Immunological Synapse Early Endosome Plasma Membrane Cell Surface Membrane Mediator Complex Anchoring Junction
	Molecular Function	Chromatin Binding Protein Binding Histone Binding NuRD Complex Binding Histone H3K36me3 Reader Activity	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcriptional Start Site Selection At RNA Polymerase II Promoter Chromatin Remodeling Positive Regulation Of Transcription Elongation By RNA Polymerase II	Positive Regulation Of Cytokine Production Adaptive Immune Response Macrophage Activation Involved In Immune Response Immune System Process Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways			Interleukin-2 family signaling
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)
Interacting Genes		2 interacting genes: HAVCR2 PLEKHF2	6 interacting genes: APP FAM200C PWWP2A SEC22A THG1L TMEM86A
Entrez ID		114825	84868
HPRD ID		19469	16227
Ensembl ID		ENSG00000170234	ENSG00000135077
Uniprot IDs		Q96N64	Q8TDQ0
PDB IDs			5DZL 5F71 6DHB 6TXZ 7KQL 7M3Y 7M3Z 7M41 8HGJ 8TBB 8TFT
Enriched GO Terms of Interacting Partners?		Early Endosome Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Immunological Synapse Formation Natural Killer Cell Tolerance Induction Negative Regulation Of Defense Response To Bacterium Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Tolerance Induction Dependent Upon Immune Response Toll-like Receptor 7 Signaling Pathway Regulation Of Macrophage Colony-stimulating Factor Production Negative Regulation Of Natural Killer Cell Activation Negative Regulation Of T-helper 1 Type Immune Response Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Defense Response To Bacterium Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Immune Response To Tumor Cell Regulation Of Defense Response To Bacterium Tolerance Induction Regulation Of Tolerance Induction Macrophage Activation Involved In Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Interleukin-4 Production Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Positive Regulation Of Macrophage Activation Regulation Of Response To Tumor Cell Maternal Process Involved In Female Pregnancy Regulation Of Interleukin-4 Production Mediator Complex Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type II Interferon Production Regulation Of Natural Killer Cell Activation Negative Regulation Of Type I Interferon Production Immunological Synapse Negative Regulation Of Interleukin-6 Production Regulation Of Natural Killer Cell Mediated Cytotoxicity Endosome To Lysosome Transport Regulation Of Macrophage Activation Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Macrophage Activation Regulation Of Interleukin-2 Production Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of T Cell Proliferation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Stress-induced Mitochondrial Fusion TRNA Guanylyltransferase Activity Regulation Of Transcriptional Start Site Selection At RNA Polymerase II Promoter NuRD Complex Binding Alkenylglycerophosphocholine Hydrolase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Protein Homooligomerization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Histone H3K36me3 Reader Activity Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Protein Complex Oligomerization Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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