COPE and SCYL1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology)

		COPE	SCYL1
Description		coat protein complex I subunit epsilon	SCY1 like pseudokinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Centrosome Cytosol Cytoskeleton Membrane COPI Vesicle Coat
	Molecular Function	Structural Molecule Activity Protein Binding	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Axon	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Intracellular Protein Localization Vesicle-mediated Transport Spinal Cord Motor Neuron Differentiation Neuron Development
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs			Grn163l
Diseases
GWAS			Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Hip index ( 34021172) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)
Interacting Genes		15 interacting genes: ARF1 CDC42 CDC42EP3 COPA COPB1 COPG1 COPG2 EFHC2 ERCC6 GDF15 MBD1 RCHY1 SCYL1 TMED10 WBP2	21 interacting genes: APP ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPE DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 SNCA TCEA2
Entrez ID		11316	57410
HPRD ID		06089	06414
Ensembl ID		ENSG00000105669	ENSG00000142186
Uniprot IDs		M0QXB4 O14579	E9PK59 E9PPN3 Q96KG9
PDB IDs		6TZT 6U3V
Enriched GO Terms of Interacting Partners?		COPI Vesicle Coat COPI-coated Vesicle COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Coat Transport Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Vesicle Transport Golgi Membrane Vesicle-mediated Transport Intracellular Protein Localization Intracellular Protein Transport Golgi Apparatus Structural Molecule Activity Establishment Of Golgi Localization Intracellular Transport Establishment Of Protein Localization Positive Regulation Of Pseudopodium Assembly Organelle Transport Along Microtubule Golgi Localization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Protein Transport Microtubule-based Movement Dendritic Spine Organization Transport Along Microtubule Cytoplasmic Vesicle Neuron Projection Organization Postsynapse Organization Cytoskeleton-dependent Intracellular Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Microtubule-based Transport Secretion Response To Metformin Cytoskeletal Regulatory Protein Binding Cytosol To ERGIC Protein Transport Cis-Golgi Network Protein Localization To ERGIC COPI-coated Vesicle Budding Cell Leading Edge Regulation Of Actin Filament Organization Establishment Of Organelle Localization Cleavage Furrow Ingression GBD Domain Binding Storage Vacuole Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	Positive Regulation Of Catabolic Process Intracellular Transport Regulation Of Protein Metabolic Process Vesicle-mediated Transport Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Macrophage Activation Protein Localization To Axon Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Protein Domain Specific Binding COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat I-SMAD Binding Positive Regulation Of JNK Cascade Cellular Localization Regulation Of Neurotransmitter Uptake Copper Ion Homeostasis Transport Vesicle Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cytoplasmic Vesicle R-SMAD Binding Myeloid Leukocyte Activation Amyloid Fibril Formation Establishment Of Protein Localization Growth Cone Microglial Cell Activation Negative Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Golgi Apparatus Mitotic Cleavage Furrow Ingression Intra-Golgi Vesicle-mediated Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cis-trans Isomerase Activity
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