SCYL1 and CHD1L

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SCYL1	CHD1L
Description		SCY1 like pseudokinase 1	chromodomain helicase DNA binding protein 1 like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Centrosome Cytosol Cytoskeleton Membrane COPI Vesicle Coat	Nucleus Nucleoplasm Chromosome Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Cadherin Binding	Nucleotide Binding DNA Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Reader Activity ATP-dependent Chromatin Remodeler Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Intracellular Protein Localization Vesicle-mediated Transport Spinal Cord Motor Neuron Differentiation Neuron Development	DNA Repair Chromatin Remodeling DNA Damage Response
Pathways			Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs		Grn163l
Diseases
GWAS		Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Hip index ( 34021172) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)	Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 25760438)
Interacting Genes		21 interacting genes: APP ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPE DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 SNCA TCEA2	7 interacting genes: BAALC CTCF NR4A1 PDE4DIP SCYL1 SRPK2 TRIM33
Entrez ID		57410	9557
HPRD ID		06414	09880
Ensembl ID		ENSG00000142186	ENSG00000131778
Uniprot IDs		E9PK59 E9PPN3 Q96KG9	A0A0A0MRH8 A0A0A0MSH9 Q86WJ1
PDB IDs			6ZHX 6ZHY 7ENN 7EPU 7OTQ 8B0A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Intracellular Transport Regulation Of Protein Metabolic Process Vesicle-mediated Transport Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Macrophage Activation Protein Localization To Axon Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Protein Domain Specific Binding COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat I-SMAD Binding Positive Regulation Of JNK Cascade Cellular Localization Regulation Of Neurotransmitter Uptake Copper Ion Homeostasis Transport Vesicle Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cytoplasmic Vesicle R-SMAD Binding Myeloid Leukocyte Activation Amyloid Fibril Formation Establishment Of Protein Localization Growth Cone Microglial Cell Activation Negative Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Golgi Apparatus Mitotic Cleavage Furrow Ingression Intra-Golgi Vesicle-mediated Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cis-trans Isomerase Activity
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